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-biomolecule immobilization. • Experience with enzyme kinetics, protein binding assays, quantification of molecular dissociation rates. • Knowledge of spin-to-charge conversion, chirality-induced spin
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University of Miami Desai Sethi Urology Institute | Miami, Florida | United States | about 1 month ago
for novel therapeutic targets We discovered the first example of a gain-of-function in a steroid-synthesizing enzyme that enables prostate cancer resistance to hormonal therapy (Chang, et al.Cell . 2013;154
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systems (proteins, enzymes, membranes, and complexes) Integrate AI/ML approaches with physics-based simulations to accelerate discovery and improve predictive fidelity Contribute to cross-scale modeling
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pathophysiology that results from genetic mutations in mitochondrial proteins, chromatin regulators, and metabolic enzymes. We interpret our experiments in the context of curated clinical phenotypes and validate
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optimization; bioprospecting for novel microbial hosts, enzymes, and metabolites to support sustainable biomanufacturing. (Bio)pharmaceuticals: Processing science and technology for bio- and chemical
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their metabolism through enzyme complexes and their interaction with cellular organelles. We combine mass spectrometry imaging, biochemistry, structural biology, and cell biology to examine metabolism in single
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to explore enzymes from diverse origins to discover novel biocatalysts for synthesizing pharmaceutically relevant compounds and to create structural diversity of natural products for drug discovery
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to cutting-edge resources and core facilities. Potential projects encompass the characterization of novel mutant animal and cell culture models showing cell autonomous effect of lysosomal enzyme deficiency in