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cognitive impairment. The project combines in vivo disease models with advanced cellular and molecular approaches, including electrophysiology, high-resolution imaging, molecular biology and ultrastructural
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We are looking for an experienced researcher whose expertise lies in mechanistic cardiac electrophysiology modelling, to work with Prof. Gary Mirams and Prof. Simon Preston on an externally-funded
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experience in sensory neuroscience, neural circuits or neurodevelopmental disorders. Experience with animal models, electrophysiology, behavioural assays and genetic techniques. Proven ability to design
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analysis. Experience with ion channels, GPCRs or TRP channels, plate-reader-based assays, high-throughput screening, Xenopus oocyte expression or electrophysiology would be advantageous. Preferably using R
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anatomy and electrophysiology. These models will be used to reconstruct the arrhythmia substrate, simulate treatment strategies and support clinical decisionmaking. The project will also investigate how
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experience in drug discovery using patch clamp electrophysiology or who can bring a new technology or perspective to bear on the work in the lab. The work is based on electrophysiological recordings using
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analysis. Experience with ion channels, GPCRs or TRP channels, plate-reader-based assays, high-throughput screening, Xenopus oocyte expression or electrophysiology would be advantageous. Preferably using R
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digital twins at scale. The doctoral candidate will create computational approaches capable of estimating anatomical, mechanical and electrophysiological parameters from large imaging datasets while
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mechanisms underlying neuromodulation in the auditory midbrain. The Roberts Lab uses cutting-edge in vivo and in vitro electrophysiology, optogenetics, molecular genetics, and anatomical approaches to identify
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leukodystrophies. Our research integrates cellular, genetic, pharmacological, electrophysiological, and behavioral approaches to understand mechanisms of oligodendrocyte dysfunction, neuroinflammation, and myelin