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the development of analytical methodologies, from both instrumentation and informatics standpoints, for the multifaceted and convoluted data that are obtained from complex biological, chemical, and forensic samples
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RAP opportunity at National Institute of Standards and Technology NIST Differentiation of Analytical and Biological Variability in Metabolomics using Standard Reference Materials and
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Analytical Technology for Biopharmaceutical Process and Product Characterization NIST only participates in the February and August reviews. Biopharmaceuticals are protein-based therapeutics produced
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technologies and affiliated hyphenated analysis techniques such as liquid chromatography coupled to HRAM-MS for chemical fingerprinting; (3) investigation of chemometric and other data analytical methods
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significantly expanding metabolome coverage; however, the complexity of the metabolome still poses significant analytical challenges. Additionally, analytical data from instrumental platforms can be more variable
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NIST only participates in the February and August reviews. This research opportunity is focused on developing advanced chemical characterization and analytical chemistry tools, data and research
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involving an actual or planned nuclear attack. Conclusions drawn from this collected data coupled with law enforcement and intelligence information may support attribution—the identification of those
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the rigorous data quality metrics for accurate diagnostics, prognostics, medical biomarkers, and for untangling the mechanisms of disease. The development and delivery of solution-enabling metrology tools
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pushed the limits of mass detection to spectral resolutions over 100,000, allowing for specific mass determination and unknown compound identification. Analytical methods and novel data-processing tools
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NIST only participates in the February and August reviews. This suite of projects seeks to advance the microbial metabolomics infrastructure through the development of new analytical methods