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, astrocytes, oligodendrocytes, and microglia. Develop complex neuroimmune co-culture systems incorporating immune cells into human CNS models. Apply CRISPR/Cas-based genome engineering technologies
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, CRISPR-based approaches, transfection/transduction, and in vitro bacterial infection models. Apply omics approaches (e.g., epigenomics, transcriptomics, proteomics) to support drug targetidentification and
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out experiments using established protocols, including work with immortalized cell lines and induced pluripotent stem cell (iPSC) models. Experimental approaches will span high-content imaging CRISPR
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at the molecular and tissue level, and how its disruption contributes to hereditary cancers and pediatric malignancies (https://bcchr.ca/maxwell-lab ). Key areas include: Mechanisms of cell division fidelity
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Research Institute and UBC, investigates how cell division is regulated at the molecular and tissue level, and how its disruption contributes to hereditary cancers and pediatric malignancies (https
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regulated at the molecular and tissue level, and how its disruption contributes to hereditary cancers and pediatric malignancies (https://bcchr.ca/maxwell-lab ). Key areas include: Mechanisms of cell