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single molecules using fluorescent nanoparticles or super-resolution. Summary of the scientific project: Understanding many complex diseases and designing rational treatments requires research on multiple
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-year research assistant position to work on the “Math-O-Meter” project, led by Marie Amalric. Project description The project aims to follow the integration of new mathematical concepts across the school
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Junior Professor Chairs have been awarded within the CRESS (2023): François Petit (Inserm), mathematician, whose applied mathematics project, "Mathematical approach for the individualization and evaluation
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well as the characterization by mass spectrometry of the components of supramolecular complexes discovered in the laboratory that are involved in NF-κB activation. We have also demonstrated their constitutive presence in tumor
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-canonical caspase substrates; multicolor/spectral flow cytometry; RT-qPCR, Western blot and cytokine assays; phagocytosis and T-cell functional assays; analysis of primary AML samples. The project will also
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integration of theoretical and experimental approaches to redefine biological questions, develop innovative experimental strategies, and enhance data analysis and modeling of complex biological systems. It aims
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approaches to complex chronic diseases. It fits fully within the priorities of the Inserm Strategic Plan, particularly the axis dedicated to cardiovascular and brain health and integrative approaches
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the understanding of the complex biological mechanisms underlying oncogenesis and therapeutic resistance, ultimately improving outcomes for patients suffering from hard-to-cure neoplasms. Inserm will invest in
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of disabilities and the reduction of costs related to complex bone reconstructions. The recruitment of a CPJ for this project is fully aligned with Inserm's 2020-2025 Strategic Plan because it reinforces
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recognition, signaling pathways and functional responses of T cells in order to enhance their activity in complex pathological environments such as solid tumors. The research program will explore strategies