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, the Giustacchini group aim to develop stem-cell-based models of paediatric leukaemia to understand how malignant haematopoiesis interacts with the immune system and to improve responses to CAR T-cell therapy. We
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-editing interventions are based on our discoveries that specific ECM components, and their post-translational glycosylations, control immune cell positioning and function within tumours. By precisely
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