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Title of the Position: Postdoctoral Associate in Pharmacoepidemiology: Drug Repurposing and Target Trial Emulations in Addiction Department and School: Department of Internal Medicine, Yale School
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samples. The lab seeks to uncover new therapeutic targets in cancer by bridging single-cell sequencing with high-throughput immune/cancer cell co-culture screens (PMID: 33483338, PMID: 40799546, PMID
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-based perturbations, base/prime editing, and targeted epigenetic modulation). Functional genomics in neuronal systems, including transcriptomic and epigenomic profiling. Model systems such as human iPSC
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biology, mitochondrial biology, and neuro-immune signaling, with the long-term goal of developing new therapeutic targets for gut motility disorders and peripheral neuropathies. The laboratory is cross
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mechanistic interrogations using models, such as conditional knock-out or CRISPR-mediated targeted insertion. The goal is to understand T cell homeostasis in the context of viral infection, chronic infection
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relevant biological pathways and novel pharmacological treatments that target these pathways. Overview of the Position The Hoffman lab seeks a full-time postdoctoral associate to work on the NIMH-funded
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on a series of scholarly articles that utilize and publicize the research collected in this database; (e) producing a suite of targeted materials aimed at policymakers and organizational leaders in