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” experimentalists in the research group and with interdisciplinary collaborating scientists. Elements of the experimental approach will include: Bayesian reconstruction of events on billion-year timescales
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hematological neoplasms and aberrant cell signaling. Utilizing multi-omics, mouse models (GEMMs/PDXs), and human biospecimens, the incumbent will conduct independent research to uncover novel therapeutic targets
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for inclusion in manuscripts and grant proposals. Essential Duties and Responsibilities include the following: Conducts research experiments to understand the mechanisms that result in diet and cancer and target
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. · Defining cellular defense pathways induced by collateral RNA cleavage, with a focus on defense mechanisms triggered by tRNA cleavage. · Investigating spacer acquisition in RNA-targeting type VI CRISPR-Cas
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diversity of endothelial cell surfaces towards identifying new vascular targeted pharmacologics for clinical translation. Essential Duties and Responsibilities include the following: Performs independent
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Associate will conduct genetic, microbiological, biochemical and animal studies to identify compounds that inhibit or kill Mycobacterium tuberculosis and to better understand their targets and mechanisms
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will conduct genetic, microbiological, biochemical and animal studies to identify compounds that inhibit or kill Mycobacterium tuberculosis and to better understand their targets and mechanisms of action
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Associate will conduct genetic, microbiological, biochemical and animal studies to identify compounds that inhibit or kill Mycobacterium tuberculosis and to better understand their targets and mechanisms
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biology, enzymology, crystallographic fragment screening, and structure-guided drug discovery to define novel mechanisms of RT inhibition and develop new approaches for targeting protein–nucleic acid
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) the regulation and function of tumor suppressor p53 and its gain-of-function mutants in cancer; 2) the role of tumor suppressors, including p53 and its target genes, in tumor microenvironment and tumor immunology