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cancer. The role involves designing and executing complex experimental studies involving drug target evaluation, molecular pharmacology, cell culture models, and in vivo xenografts to evaluate targeted
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novel metabolic vulnerabilities in KRAS-mutant lung cancer using in vivo and in vitro screening approaches; (ii) validate identified targets in vivo and elucidate the underlying mechanisms; and (iii
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hematological neoplasms and aberrant cell signaling. Utilizing multi-omics, mouse models (GEMMs/PDXs), and human biospecimens, the incumbent will conduct independent research to uncover novel therapeutic targets
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for inclusion in manuscripts and grant proposals. Essential Duties and Responsibilities include the following: Conducts research experiments to understand the mechanisms that result in diet and cancer and target
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diversity of endothelial cell surfaces towards identifying new vascular targeted pharmacologics for clinical translation. Essential Duties and Responsibilities include the following: Performs independent
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biology, enzymology, crystallographic fragment screening, and structure-guided drug discovery to define novel mechanisms of RT inhibition and develop new approaches for targeting protein–nucleic acid
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) the regulation and function of tumor suppressor p53 and its gain-of-function mutants in cancer; 2) the role of tumor suppressors, including p53 and its target genes, in tumor microenvironment and tumor immunology
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Associate will work on a project in a laboratory dedicated to studying the molecular pathogenesis of Parkinson’s Disease and related disorders, identifying therapeutic targets and testing new therapeutic
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fundamental questions. Active areas of research include T cell receptor discovery, membrane-tethered cytokine technologies, tumor resistance mutations, target antigen discovery, and preclinical development