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and molecular biology approaches, flow cytometry, and transcriptomic and epigenomic analyses. The ultimate goal is to identify the mechanisms driving the age-associated loss of stem cell function and to
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networks. Alzheimer's disease is associated with early alterations in cholesterol metabolism, lipid droplet accumulation, mitochondrial dysfunction, and defective autophagy, particularly in APOE4 carriers
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to investigate how ageing-associated microenvironments affect human adipose tissue physiology. By perfusing the engineered tissues with sera from young and aged donors, the project will evaluate changes in adipose
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