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the mitochondrial dysfunction associated with neurodegeneration and the metabolic advantage and resistance to apoptosis exhibited by cancer cells. To this end, RNA molecules encoding interfering peptides will be
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of cellular photobiology: cytotoxic effects induced by the generation of reactive species (cell death mechanisms – apoptosis vs. necrosis). Work Location(s) Number of offers available1Company/InstituteNational
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for tumor cell survival, and acting through the recruitment of the RNA helicase DHX36 to modulate the translation of mRNAs enriched in G-quadruplex motifs. Silencing of LENT induces apoptosis, highlighting
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Ecole Supérieure De Biologie Biochimie Et Biotechnologies (Université Catholique de Lyon) | Lyon, Rhone Alpes | France | 3 months ago
on the induction of apoptosis in tumor cells often show limited long-term efficacy due to the ability of cancer cells to develop resistance mechanisms. To improve therapeutic outcomes, conventional treatments
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cells. Our pilot research has revealed that A. phagocytophilum effectors have wide reaching impacts on host cells, including the remodelling the host cytoskeleton and inhibition of apoptosis, and how
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inhibition of apoptosis, and how these effector functions enable an intracellular lifestyle. Please see this short video for a brief overview of some of our work: https://www.youtube.com/watch?v=aa_GTkPq-RA
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apoptosis assays. Support 3D spheroid generation, maintenance, and drug response assays, including IncuCyte based spheroid imaging and quantification. Support drug response experiments, including viability
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microvascular dysfunction in diabetes and menopause, particularly in cell-cell communication, mitochondrial function, cell apoptosis/senescence, and calcium handling in the endoplasmic reticulum of endothelial
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apoptosis. Riley et al, EMBO J (2018)37:e99238 https://doi.org/10.15252/embj.201899238 Mitochondrial outer membrane integrity regulates a ubiquitin-dependent NF-κB inflammatory response. Vringer et al, doi
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. Network Science. Cambridge University Press. 2016. http://networksciencebook.com/ Wu Z, Trevino AE, Wu E, et al. Graph deep learning for the characterization of tumour microenvironments from spatial protein