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combination with tissue-specific manipulations (via RNAi), metabolomics mass spectrometry, and cell biology including fluorescence microscopy. The project builds on preexisting mutants and protocols
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cells, scRNAseq, spatial transcriptomics, proteomics (mass spectrometry, multiplex ELISA techniques). Working with patient derived samples and thus some flexibility regarding timing of the planned
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mechanism The PhD student will work on the molecular mechanisms underlying this entirely new form of gene dosage control. We will use next-generation sequencing and mass spectrometry to characterize
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the necessary support with mass spectrometry, sequencing and flow cytometry requirements of the project. If you are interested in this project, please select Khmelinskii (Khme) as your group preference in the IPP
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. To this end, she/he will search for new L-Cry interactors using pulldown/mass spectrometry (MS) under dark, sunlight and moonlight conditions, and mechanistically and functionally characterize
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fluorescence microscopy, chromatin immunoprecipitation, next-generation sequencing, and quantitative mass spectrometry, to examine the influence of factors like chromatin structure, cell cycle, and replication