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, regulates this process, though specifics remain unclear. The relevance of this process for human disease is also still unclear. Our project aims to decipher the ubiquitin code governing MDV-mediated quality
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in the LE disease process would facilitate early diagnosis and reveal targets for early intervention, changing the current paradigm from ‘long-term management of chronic inflammation’ to ‘prevention
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the BBB, the T cells must be reactivated. It is currently unknown which kind of APCs are involved in this process. A specific cell population we are interested in are the endothelial cells of the blood
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to understanding the molecular events of the aging process. Various types of abnormal proteins are recognized by the ubiquitin-proteasome system via short motifs called degrons and marked for proteasomal degradation
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or diminished RS protein levels corroborated their functional relevance in this process. Interestingly, RS proteins mainly localize in the nucleoplasm of etiolated seedlings, while light exposure can trigger
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or Autism spectrum disorder. They manifest as brain abnormalities, intellectual disabilities and other physical aberrations. The molecular and cellular consequences of these mutations are hardly known so far
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/β-catenin signaling. The cell adhesion molecule E-cadherin is only expressed by LC and we recently showed that it is involved in the 2-step process of their differentiation in the oral mucosa. Notably
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multitude of factors, including the ubiquitylation of the replication factor PCNA, have been implicated in this process, but many questions remain: what determines whether a replisome stalls or simply moves
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cancer. The regulation of gene activation is achieved via a complex, multi-step process that starts by the recognition of DNA enhancer elements through gene-specific transcription factors which recruit