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the mutational complexity and immune interactions of human cancer. We recently published an article (Nature Genetics, 2023) describing mouse models of lung and colon cancer with DNA mismatch repair deficiency
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behaviors. Genes that determine such behavioral differences, for example between the singing mouse and the lab mouse, must act via neural circuits within the brain. Yet, the structural and functional changes
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roles of genes associated with human diseases in the development and function of neural circuits, using molecular, genetic and viral engineering, optogenetics, imaging, electrophysiology, and behavior
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controls alternative mRNA splicing in humans. Research pursued by the postdoctoral fellow will likely involve the use of massively parallel reporter assays (MPRAs) and/or the development of deep neural
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technologies. The candidate will work closely with bench scientists to draft the initial computational workflows to analyze new experimental data. Developing a relationship of feedback and understanding between