Research Associate/Fellow - Stem cell derived-cardiomyocytes to evaluate therapies for genetic disorders of the heart
- Closing Date
- Friday, 14th September 2012
- Job Type
- Research & Teaching
- School of Clinical Sciences - Centre for Stem Cells Tissue Engineering & Modelling
- £24520 to £32901 per annum, depending on skills and experience (minimum £27,578 per annum with relevant PhD)
This post will be offered for an indefinite period however the funding that supports this post is available for two years from date of commencement.
Applications are invited for the above post based within the School of Clinical Sciences, STEM. This post provides an exciting opportunity to join the Department of Stem Cells, Tissue Engineering & Modelling (STEM) at the University of Nottingham. The department comprises of a team of scientists with an interest in combining a range of state-of the art stem cell technologies to answer key biomedical questions, including those relating to heart disease.
Long QT syndrome (LQTS) is a genetic disorder that can lead to sudden cardiac death. Our previous work (Matsa et al., European Heart Journal) has shown that human induced pluripotent stem cell (hiPSC) derived cardiomyocytes carrying LQTS2 develop spontaneous and drug induced arrhythmias in a manner similar to those seen in the patients. We will now extend these findings to characterise the LQTS hiPSC-cardiomyocytes in more detail. The successful candidate will derive hiPSC lines and carry out hPSC culture, cardiac differentiation and analysis of cell function, with particular emphasis on patch clamp electrophysiology, pharmacology and/or bioinformatics. The successful candidate should have skills in most of these areas.
Candidates should be nearing completion of a PhD or hold a PhD in the biological sciences or equivalent. Other essential skills will include gene cloning, genetic modification and immuno analysis (e.g. flow cytometry, immunostaining, westerns). They must have a good publication track record and have presented the data in seminars to international audiences of scientists and the public. They will have a proven ability to collaborate with other institutions and work in a team.
Informal enquiries may be addressed to Professor Chris Denning, email: firstname.lastname@example.org. Please note that applications sent directly to this email address will not be accepted.
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