Research Assistant / Associate (ref. 17171), University of Bristol

Contract:

Fixed Term Contract (45 months)

Salary:

£30,122 - £38,140

Grade:

Level a - Level b in Pathway 2

Closing date for applications:

9:00am 08 Jun 2012

This post will investigate the molecular cell biology of platelet formation. Platelets are small cells involved in blood clotting and thrombosis in many disease settings, particularly heart disease and stroke. They bud from large bone marrow-derived stem cells called megakaryocytes, and the process of their birth is currently not known. We have evidence that this is regulated by a series of protein kinase-dependent events, including by protein kinase C-alpha.
The project will use a variety of state-of-the-art molecular approaches, including lentiviral expression of constructs in primary human and mouse haematopoietic stem cells and advanced light and electron microscopic imaging approaches to address how platelets are formed in-vitro and in-vivo. We are a highly active lab with an international reputation in the field of platelet cell biology. The lab forms part of the Bristol Platelet Group (www.bristolplatelets.org), where there is significant and well-funded critical mass in investigating these cells in health and disease contexts.
We are looking for a highly ambitious self-starter with an outstanding background in molecular cell biology, particularly with advanced microscopy experience, to join our group to take on this exciting project.
If successful, you may be appointed either on a fixed-term or an open-ended contract depending on the extent of your previous relevant research experience. Three years’ appropriate and relevant experience at another higher education institution would normally lead to an appointment on an open-ended contract. Further information can be found at www.bristol.ac.uk/hr/ftc/

Download full details (17171fds.doc)

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Contact for informal enquiries:

Professor A Poole (a.poole@bristol.ac.uk | 0117 331 1435)