PhD Studentship in Pectin supplementation to reduce gut and systemic inflammation and improve liver, muscle and gastrointestinal outcomes
Non-alcoholic fatty liver disease (NAFLD) affects a quarter of the global population, representing a major driver for cirrhosis, metabolic syndrome and cardiovascular diseases. In its advance stages, liver fibrosis and inflammation often lead to muscle wasting and loss of muscle mass due. This process, known as cachexia, is often a result of systemic inflammation and altered protein metabolism, negatively impacting the overall health and strength.
Reversing liver fibrosis and inflammation is achievable through 10% weight loss and exercise but these require intense supervision and have low adherence. Strategies based on dietary supplementation, instead, are easy and cost-effective both to adhere and to deliver.
Research has shown that pectins (plant polysaccharides used as food additives) can reduce inflammation through various mechanisms, in particular by antagonising an immune pathway called TLR2. Animals lacking TLR2 do not develop liver fibrosis, liver inflammation, and metabolic syndrome traits, and are protected from cachexia.
Our own studies in healthy volunteers show that supplementation with 15-20g of pectin per day significantly reduces systemic inflammation and gut permeability and have no side effects.
This research project will explore the efficacy on gut permeability, liver and systemic inflammation and muscle mass of pectin supplementation among individuals diagnosed with non-alcoholic liver disease. The project will also explore the benefits of pectin supplementation among individuals awaiting colorectal surgery as they will also benefit from reduced gut permeability and systemic inflammation.
This project will use cutting-edge magnetic resonance imaging to assess the various outcomes in addition to a number of circulating biomarkers and functional assessments.
Working in a multidisciplinary environment and taking advantage of the expertise at the gastrointestinal and musculoskeletal Nottingham BRC themes, this project will enable the successful candidate to develop state-of-the art biomedical skills and hands-on experience in clinical research, as well as developing specific analytical skills and techniques.
The student will be able to work within well-funded and vibrant groups with support from several PDRAs. They will interreact with a variety of fundamental, translational, and industry-led projects, as well as interacting with partners in the Nottingham Biomedical Research Centre (https://nottinghambrc.nihr.ac.uk/ ).
The student will be registered within the School of Medicine.
Funding notes: The three-year studentship covers tuition fees and a tax-free stipend. Due to funding requirements, only applications from domestic students will be accepted.
Supervisors:
Prof Guru Aithal (Professor of Hepatology, School of Medicine, University of Nottingham)
Dr Jane Grove (Assistant Professor in Translational Sciences, School of Medicine, University of Nottingham)
Dr Katie Rollins (Associate Professor in Colorectal Surgery, School of Medicine, University of Nottingham
Prof Ana Valdes (Professor in Genetic and Molecular Epidemiology, School of Medicine, University of Nottingham)
Application Details: To apply for this PhD opportunity, please submit the following documents to [email protected]
- Cover Letter outlining your research interests and motivation to pursue this project.
- Curriculum Vitae detailing your academic background, research experience and relevant skills.
Please include the title of the PhD in the subject of the email.
Entry Requirements:
At least a 2.1 Honours degree in Pharmacy, Biomedical Engineering, Biological Sciences, Bioengineering or any related field.
Start Date: July 2024
Informal inquiries can be made to:[email protected]