PhD studentship (Fixed Term)

Updated: about 20 hours ago
Location: Cambridge, ENGLAND
Deadline: 18 Aug 2017

PhD studentship in Biochemistry/Molecular Cell Biology/Neuroscience in Cambridge

A fully funded 4-year PhD studentship is available, as a BBSRC Collaborative Training Partnership (CTP) between AstraZeneca and the University of Cambridge, commencing in October 2017, with a project titled "Understanding the roles of CD33 variants on microglial activation".

Microglia are brain macrophages that phagocytose synapses, neurons and protein aggregates, and regulate inflammation in the brain. During ageing, the brain becomes inflamed and the microglia change function in a variety of ways. This project aims to determine whether these microglial changes contribute to or combat brain ageing, and thereby improve our fundamental knowledge of microglia and the aging brain. We will use Molecular Cell Biology to understand the role of CD33 and other microglial receptors in these processes.

References: Villegas-Llerena C et al (2016). Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease. Curr Opin Neurobiol. 36:74-81.

Brown GC & Neher JJ (2014) Microglial phagocytosis of live neurons. Nat. Rev. Neurosci. 15, 209-216.

The aim of the BBSRC CTP awards is to provide PhD students with a challenging research training experience within the context of a mutually beneficial research collaboration, between academic and industrial partner organisations. The student will based in the laboratory of Prof. Guy Brown in the Department of Biochemistry, University of Cambridge, and that of Dr Maria Herva and other scientists at AstraZeneca in Cambridge, and will be jointly supervised.

Applicants should hold a First or Upper-Second (2.i) class degree in a relevant subject. BBSRC studentships are available to UK nationals and EU students who meet the UK residency requirements. Further information about eligibility for Research Council UK funding can be found on the BBSRC website: The successful candidate will receive a stipend paid at RCUK rates for the 4 year duration of the award (£14,296 per annum for 2016-17); fees will be met in full for UK nationals or EU nationals meeting BBSRC residency requirements.

Fixed-term: The funds for this post are available for 4 years.

Applications should be sent to Prof. Guy Brown ( ) by 18th August 2017, enclosing a cover letter, a detailed curriculum vitae and the names and contact details of two academic referees.

Please quote reference PH12957 on your application and in any correspondence about this vacancy.

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