- Job Type
- Research & Teaching
- Schools of Computer Science, Mathematics & Biosciences
Fully Funded PhD Studentship in Plants Systems Biology
Supervisors: Professor Natalio Krasnogor (School of Computer Science), Professor Andrew Wood (School of Mathematics), Professor Michael Holdsworth (School of Biosciences).
In this project, the student will work at the interface of Computer Science, Mathematics and Biology developing cutting-edge bioinformatics software applied to the understanding of complex biological networks:
(Multi)Cellular processes and pathways, whose deregulation may contribute to the development of biological ailments, are often represented as cascades of proteins transmitting a signal from the cell surface to the nucleus. However, recent functional genomic experiments have identified thousands of interactions for the canonical signalling proteins, challenging the traditional view of pathways as independent functional entities. Combining information from pathway databases and interaction networks obtained from, e.g., functional genomic experiments is therefore a promising strategy for obtaining more robust pathway and process representations, facilitating the study of biological functionality.
This studentship will seek to extend work done at Nottingham on network-centric biology by integrating multiple information sources across different species and analyzing the resulting networks/graphs within and across species. The PhD candidate will investigate graph theoretical algorithms, high-performance computing, biological databases as well as advanced statistics with a view of creating biological-relevant and user-friendly bioinformatics tools. The successful student will have opportunities to visit international collaborators and will become members of a very active community of interdisciplinary researchers at Nottingham.
Students should have a 1st class undergraduate or masters degree in Computer Science, Mathematics, Statistics or a related discipline. A background in Biology is not required but a willingness to learn relevant biology is essential. Students should be highly numerate and experienced programmers andshould possess excellent communication skills, be keen to work as part of a multidisciplinary team, be self-driven and highly motivated.
This fully-funded studentship (stipends + fees) is available for three years. Due to funding restrictions this studentship is only open to UK students.
Informal enquiries may be addressed to: Professor Krasnogor, email: email@example.com. Professor Andrew Wood, email: Andrew.Wood@nottingham.ac.uk or Professor Michael Holdsworth, email: firstname.lastname@example.org. Please note that applications sent directly to either of those Email addresses will not be accepted. Additional information is available at www.cs.nott.ac.uk/~nxk
Students should send a complete application including all of the following: (1) covering letter, (2) full CV with transcripts (including expected or actual degree class), (3) the names and Email addresses of at least 2 (ideally 3 or more) academic referees. Full applications should be sent by email to Nicholas Poxon, email: email@example.com. Please quote ref. SCI/1035.
Closing date: The studentship will be filled when suitable students have been identified. Early application is strongly recommended.