Applications are invited for a fully-funded 3-year studentship based in the Department of Pathology at the University of Cambridge under the supervision of Prof Nicholas Coleman and Dr Anton Enright.
Project title: Investigating Alternative Splicing As A Driver Mechanism And Therapeutic Target In Squamous Cell Carcinoma
Squamous cell carcinomas (SCCs) are common malignancies that arise at sites including the skin, aerodigestive tract and genitourinary tract. Despite different SCCs being associated with at least one carcinogenic insult (e.g. tobacco, human papillomavirus infection and UV damage), the drivers of SCC carcinogenesis remain largely elusive. Our lab is testing the hypothesis that aberrant RNA splicing is a central mechanism of carcinogenesis in SCCs. We have recently shown that splicing dysregulation in SCCs is not a passenger phenomenon, but likely constitutes a critical driver of oncogenesis, reflected by splicing aberrations in hallmark- related genes across SCC subtypes and a difference in splicing regulation compared with healthy tissues and other tumour types.
This studentship will allow us to advance our understanding of how splicing contributes to oncogenesis in SCC and whether it is a vulnerability that can be targeted therapeutically.
Our objectives will be:
This is a three year PhD studentship, funded by The Pathological Society of Great Britain and Ireland.
It involves a combination of computational and wet lab research.
Applicants should hold (or expect to obtain) the equivalent of a UK 2.1 or higher in an undergraduate honours or Masters degree in a relevant subject such as molecular biology, genetics or computational biology. The studentship is open to those eligible for the Home rate of University fees.
Applications should include academic transcripts, CV, statement of purpose and two references.
Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.
If you have any queries regarding the application process please contact [email protected]
Please quote reference PK40360 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
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