PhD student position: deciphering the molecular basis of allostery in CRISPR associated proteins using single-molecule experiments
12 Mar 2024
Job Information
- Organisation/Company
University of Basel- Research Field
Chemistry » Biochemistry
Chemistry » Physical chemistry
Chemistry » Other- Researcher Profile
First Stage Researcher (R1)- Country
Switzerland- Application Deadline
30 Apr 2024 - 21:59 (UTC)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
38- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
The Biomolecular Nano-Dynamics group at the Dept. of Chemistry, University of Basel is looking for a highly talented and motivated PhD student with a background in (bio-)physics, or biophysical chemistry to join our team for the study of allosteric mechanisms governing recently discovered CRISPR associated proteins using novel techniques, such as single-molecule fluorescence/FRET and nanopore trapping.
This PhD project will grow with you. You will create time-resolved direct observations of single CARF proteins – aka. CRISPR suicide proteins – undergoing allosteric activation, substrate processing, deactivation, etc. How this works, on what timescales, by which conformational rearrangements has not been observed yet in real-time, leaving the underlying molecular processes obscure. In this PhD project, you'll be able to solve (some of) these nanoscale puzzles. Steps involved in the project:
- Single-molecule fluorescence/FRET/DyeCycling experiments
- Solid-state nanopore/NEOtrap experiments
- Advanced data analysis, coding, kinetic modeling
- Protein production and functionalization
Prior experience in several of these areas is desired:
- Single-molecule experiments and interpretation
- Advanced data analysis, coding, modeling, machine learning
- Optics and fluorescence microscopy and/or nanopore techniques
- Protein biochemistry
Essential requirements:
- MSc degree in physics or (bio-)chemistry with excellent grades
- High motivation and curiosity about fundamental questions on the physical-chemistry of life
- Independent analytical thinking and systematic work style
- Excellent experimental problem-solving skills and perseverance
- Friendly team player proficient in English communication (speaking & writing)
- An exciting and fully funded PhD project in Basel, Switzerland
- Embedding in a productive, interdisciplinary group with an open and interactive lab culture
- State-of-the-art research infrastructure and facilities
- A highly international and interdisciplinary setting stimulating your professional and personal development
- The GRACE graduate center , wide-ranging sports offers , etc.
- A beautiful and very livable city at the intersection of Germany, France, and Switzerland
Application / Contact
Applications are invited before/by April 30th, 2024. Please submit your application via [email protected] with subject 'Application PhD4 Firstname Lastname', and include:
your letter of motivation, your CV, and email addresses of 2-3 references – all merged into one single pdf file named 'Application PhD4 Firstname Lastname.pdf'.
For questions, please contact Prof. Sonja Schmid: [email protected] .
Requirements
- Research Field
- Chemistry
- Years of Research Experience
- 1 - 4
- Research Field
- Chemistry
- Years of Research Experience
- 1 - 4
- Research Field
- Chemistry
- Years of Research Experience
- 1 - 4
Additional Information
- Website for additional job details
https://academicpositions.com
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- University of Basel
- Country
- Switzerland
- City
- Basel
- Postal Code
- CH-4003
- Street
- Petersplatz 1
Where to apply
- Website
https://academicpositions.com/ad/university-of-basel/2024/phd-student-position-…
Contact
- City
Basel- Website
https://www.unibas.ch/en.html- Postal Code
CH-4003
STATUS: EXPIRED
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