|has a vacancy for|
|A doctoral student with doctoral grant in Infection Biology|
Department of Medicine, Huddinge
|Description of research group and project
The research group is headed by Linda Johansson and Anna Norrby-Teglund, and is one of 17 independent groups active at the Center for Infectious Medicine. The main research goal is to decipher mechanisms contributing to severe manifestations of acute bacterial infections and thereby identify targets for therapeutic intervention. The research is translational in nature and is based largely on clinical isolates, patient materials and human cell and 3D tissue model systems that mimic the clinical setting.
Of particular interest are the two Gram-positive bacteria Streptococcus pyogenes and Staphylococcus aureus, both of which may cause highly aggressive invasive infections such as toxic shock, necrotizing pneumonia and necrotizing fasciitis that are associated with substantial morbidity and mortality. The research strives to decipher bacterial properties contributing to disease outcome and events underlying tissue injury. This project specifically aims to investigate the role of the patients´ own antibiotics, the so called antimicrobial peptide LL-37, in acute bacterial infections.
Our research focus on host-pathogen interactions and the planned studies include among others bacteriology and cell culture work, advanced microscopy, as well as molecular biology.
|Duties and responsibilities
The Ph.D. student will learn and apply different techniques for cellular and molecular biology (immunostainings, live-cell imaging, western blot, ELISA, PCR etc.). The project involves experiments with human primary cells, including infection assays with S. pyogenes and S. aureus as well as experiments with antimicrobial peptides.
The Ph.D. student will join all research-related activities such as group meetings, departmental seminars, national/international meetings, as well as standard laboratory routines of the group.
The eligible candidate we are looking for must hold a Master´s degree in biomedicine, molecular cell biology, immunology or equivalent. We are seeking a highly self-motivated, technically skilled, and creative person. The successful applicant needs to be fluent in English, have excellent communication skills and the ability to interact effectively and work productively in a team. Merit is previous lab experience and experience of international collaborations. Great advantage is experience in for example tissue culture work with primary immune cells or cell lines, bacterial cultures, peptide work and microscopy.
To be eligible, an applicant must
1. Hold a Master´s (second-cycle) degree
2. Have completed course requirements of at least 240 HECs, of which at least 60 at second-cycle level, or
3. Have an otherwise acquired essentially equivalent competence in Sweden or abroad.
Those who meet the requirements for general eligibility before July 1st, 2007, i.e. had completed a programme of higher education for at least 180 HEC or equivalent will continue to do so until the end of July, 2015.
Selection is made of qualified applicants on the ground of their ability to benefit from doctoral (third-cycle) education. Karolinska Institutet applies the following assessment criteria:
-Documented subject knowledge of significance to the research project
-Analytical skills confirmed by scientific dissertation or the equivalent
-Other documented knowledge/experience of potential significance to doctoral (third-cycle) education in the subject
An overall assessment of the applicants´qualifications will be made.
The vacancy will be filled on condition that the successful applicant is admitted to doctoral (third-cycle) education.
The PhD project is planned to last four years.
For further information on doctoral (third-cycle) education at Karolinska Institutet, see www.ki.se/doctoral.
|Form of employment:
Assistant Professor Linda Johansson
Professor Anna Norrby-Teglund
|Please send your application, marked with reference number 1808/2012, to reach us by no later than March 30 2012
KI jobb or,
to Karolinska Institutet, Department of Medicine, Huddinge, Att. Anna-Maria Bernstein, M54, S-141 86 Stockholm. The following documents should be enclosed with your application written in English:
- Personal letter of introduction explaining your interest in the position and background experience that makes you suitable for the position
- A complete CV
- Copy of degree certificate and grades
- Copy of degree dissertation and any previous publications
- Two letters of recommendation from persons working in research environments
The Department of Medicine Huddinge is engaged in research and education within a wide range of the medical field, covering all internal medicine specialties, infectious diseases and dermatology. The Department of Medicine is situated at Karolinska University Hospital in Huddinge and consists of seven units with a total of nearly 40 research groups.
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