Postdoctoral Position: 7FP Marie Curie Fellowship, GENYO

Job posted by FUNDACIÓN PROGRESO Y SALUD (19/06/2012 09.16)
Postdoctoral Position: 7FP Marie Curie Fellowship
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GENYO (www.genyo.es) is the first national centre devoted to genomics that integrates the Public Research Institutions with the pharmaceutical sector. GENYO was created as a multidisciplinary research space, where different professionals from the healthcare, university and business areas interact, making it possible to generate new systems to diagnose, prevent and treat diseases based on the joint and coordinated application of first-rate knowledge in the different areas of genetics.

Description

The Gene and Cell Therapy group directed by Francisco Martin is searching for postdoctoral researchers to apply for a Marie Curie incoming intra-European or international fellowship.
The group main interest is the development of safer and more efficient gene delivery tools for the treatment of immune-related diseases: Immunodeficiencies (Wiskott-Aldrich Syndrome) and autoimmune diseases (Multiple sclerosis).
Immunodeficiencies (Wiskott-Aldrich Syndrome). We have developed physiologically regulated lentiviral vectors expressing WASP, the affected gene in Wiskott-Aldrich Syndrome. We have also developed several cell models to study the role of WASP in cell biology and to study the safety and efficiency of GT strategies. In this direction we have recently developed several human Embryonic Stem Cells WAS Ko using Zinc Finger Nucleases (ZFNs) targeting the first intron of the WAS gene. Using this technology we can model any mutation present in nature.
Autoimmune diseases (Multiple sclerosis). In order to improve the delivery of therapeutic genes to target tissues, we have combined the efficiency and transcriptional control of lentiviral vectors with the ability to migrate to inflammatory sites of mesenchymal stem cells (MSC). In this direction we are interested on improving the migratory potential of MSC to inflamed CNS and in the development of new doxycycline-regulated lentiviral vectors that stably and efficiently modulate gene expression in this MSCs and in its progeny.

Nr of positions available : 1

Research Fields

Other

Career Stage

Experienced researcher or 4-10 yrs (Post-Doc)

Research Profile

First Stage Researcher (R1)