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determines safety factors in assessing risks to human health. This goal will be accomplished by identifying molecular key event (KE) biomarkers, predictive of chemically induced adverse health effects in
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is interested in investigating the earliest stages of molecular novelties: how newly originated genes, such as new Transcription Factors (TFs), are integrated for the first time into a biological
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sequences. More specifically, we are interested in the epigenetic regulation of gene expression and RNA processing, the relationship between molecular phenotypes and higher-order endophenotypes and organismal
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assessing risks to human health. This goal will be accomplished by identifying molecular key event (KE) biomarkers, predictive of chemically induced adverse health effects in humans, that feed directly into
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determinants. The institute applies a multidisciplinary scientific approach ranging from the molecular to the population level. Research is organised in five overarching programmes: Climate, Air Pollution