8 Feb 2024
Job Information
- Organisation/Company
Institute of Bioorganic Chemistry Polish Academy of Sciences- Department
Department of Molecular Neurobiology- Research Field
Biological sciences » Biology- Researcher Profile
First Stage Researcher (R1)- Country
Poland- Application Deadline
8 Mar 2024 - 23:00 (Europe/Brussels)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
40- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Reference Number
4/2024/ICHB/PSD- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
KEYWORDS: neurodegenerative disease, nutrition, neurodegeneration, mechanisms, multiomics, proteomics, transcriptomics, spinocerebellar ataxia 3, mutant protein, PolyQ, therapy.
Principal Investigator: Maciej Figiel
Research topic: Investigation of molecular mechanisms of dietary intervention on neurodegeneration in SCA3 / MJD
I. Project description
Despite significant advances in the field of neurodegenerative disorders, there is currently no cure available. However, a non-pharmacological intervention that induces a ketogenic metabolism in patients has shown great promise in ameliorating various neurological conditions without posing any risk to patients. This approach involves a diet that consists of 90% fat as the necessary calorie source and is currently being utilized for patients suffering from genetic neurodegenerative PolyQ disease and spinocerebellar ataxia 3 (SCA3). It is the only implemented treatment that has shown any improvement in this disorder. Our research project aims to better understand the beneficial molecular mechanisms and pathways modulated by effective dietary interventions, specifically caloric restriction, ketogenic, and Mediterranean diets, using SCA3 as a model of neurodegenerative disease. We hypothesize that these dietary regimens modulate distinct pathways, such as cellular proteolytic systems and glucose metabolism, and that this knowledge can be translated into new, even more effective regimes and/or new therapy targets that can help fight neurodegeneration. We will investigate the molecular mechanisms behind the beneficial effects of these dietary regimes by utilizing relevant knock-in mouse models for SCA3 and cutting-edge multi-omic, molecular, epigenetic and behavioral methodologies. Our goal is to provide evidence-based nutritional recommendations for patients and improve targeted interventions in neurodegenerative and related disorders, such as Alzheimer's, based on our findings
Additional information:
Requirements
- Research Field
- Biological sciences » Biology
- Education Level
- Master Degree or equivalent
Additional Information
Benefits
Ph.D. students shall receive a stipend in the gross amount of ca 4300 PLN (3800 PLN net)
II. Requirements for the candidates:
Selected skills, knowledge of which may be helpful:
III. Duties in the project:
IV. Required documents:
https://psd-ipan.ichb.pl/wp-content/uploads/2023/05/ICHBApplication_for_admission_10_05_23.docx
https://nawa.gov.pl/en/recognition/recognition-for-academic-purposes/applying-for-admission-to-doctoral-studies
V. Applications should be submitted via the eRecruiter portal at:
https://system.erecruiter.pl/FormTemplates/RecruitmentForm.aspx?WebID=dcedf7543cb148ec8a6b4d38c636bebb
VI. Submission deadline is 08.03.2024
VII. Criteria for evaluation of candidates:
Eligibility criteria
VIII. The recruitment procedure shall be concluded no latter than 08.04.2024
IX. The description of the recruitment process is stipulated in the Regulations of Recruitment for PDS IPAS. Following the recruitment procedure, the unadmitted candidates shall be informed of the number of points obtained at both stages.
Incomplete applications will not be considered.
For additional information, please contact the Principal Investigator:
Maciej Figiel
e-mail: [email protected]
Information clause:
Pursuant to the stipulations of the regulation (EU) 2016/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95/46/EC (General Data Protection Regulation), further referred to as GDPR, we hereby inform that:
- The Institute of Bioorganic Chemistry, Polish Academy of Sciences, seated in Noskowskiego St. 12/14, 61-704 Poznan; REGON 000849327, NIP 777-00-02-062 is the administrator of the collected personal data (further referred to as the Institute).
- The Administrator appointed a Data Protection Officer, who can be contacted in writing, via traditional mail, by sending a letter to the following address: Z. Noskowskiego St. 12/14, 61-704 Poznan, or by sending an e-mail to: [email protected] .
- The personal data of the candidates is processed for the purposes of fulfilling the tasks of the administrator, associated with conducting the recruitment procedure for a vacant position.
- The legal basis for processing personal data is the Act of 26 June 1974 – The Labor Code, Act of 30 April 2010 on the Polish Academy of Sciences or the consent of the person whose data shall be subjected to processing.
Selection process
- Your personal data shall be subjected to processing for a period of 3 months upon the date of the decision of the recruitment committee. Following this period, the data will be irretrievably and effectively destroyed.
- The personal data of the candidates shall not be transferred to any third country.
- The person whose data shall be subjected to processing has the right to:
- request access to his/her personal data, and to amend it or delete it, pursuant to articles 15-17 of GDPR;
- limit data processing, in the events stipulated in article 18 of GDPR;
- data transferring, pursuant to article 20 of GDPR;
- withdraw consent at any moment, without influencing compliance with the law of the processing that was executed prior to consent withdrawal;
- file a complaint to the Inspector General for Personal Data Protection.
Providing personal data in the scope stipulated in article 22 (1) of the Act of 26 June 1974 – The Labor Code is mandatory, whereas providing data in a broader scope is voluntary and requires consent for its processing.
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Institute of Bioorganic Chemistry, PAS
- Country
- Poland
- State/Province
- wielkopolska
- City
- Poznań
- Postal Code
- 61-704
- Street
- Zygmunta Noskowskiego 12/14
- Geofield
Where to apply
- Website
https://system.erecruiter.pl/FormTemplates/RecruitmentForm.aspx?WebID=dcedf7543…
Contact
- State/Province
wielkopolska- City
Poznan- Website
http://www.ibch.poznan.pl- Street
Noskowskiego 12/14- Postal Code
61-704
[email protected]
STATUS: EXPIRED
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