PI, postdocs and PhD student gene therapy and hematological disorders

6 Feb 2024
Job Information

Organisation/Company

Sanquin Blood Supply Foundation (Sanquin)

Research Field

Medical sciences
Physics

Researcher Profile

Recognised Researcher (R2)
First Stage Researcher (R1)

Country

Netherlands

Application Deadline

3 Mar 2024 - 22:59 (UTC)

Type of Contract

Temporary

Job Status

Not Applicable

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Within our research-team that focuses on bleeding and hemostasis we are now looking for one early and one mid-career group leader and 2 postdocs for our gene therapy programs. In addition we have vacancies for one mid-career PI and 2 PhD candidates for our platelet biology and rare bleeding disorders program. These new colleagues are expected to contribute to the following projects.

Gene therapy program Sanquin. The gene therapy group within Sanquin focuses on further improvement of the quality of life of patients with hematological disorder. In our program we focus on AAV-mediated gene therapy for liver disorders. Within the context of an Eurostars and Health Holland funded grant we employ capsid engineering to further improve the targeting efficacy and reduce the reactivity with pre-existing neutralizing antibodies of the current generation of gene therapy vectors. For these projects we will are looking for two postdocs with experience in AAV mediated gene therapy. In a separate line of research we aim to establish non-viral approaches for in vivo targeting of hematopoietic stem cells. For this program we are looking for a postdoc or junior group leader with experience in nanoparticle mediated gene delivery as well as gene-editing. The mid-career PI we are recruiting is expected to contribute to both programs and preferably has experience with both viral and non-viral based gene delivery technologies.

Platelet biology and rare bleeding disorder program. Within the platelet biology group of Sanquin we aim to dissect critical biological pathways involved in the production of platelets from bone marrow localized megakaryocytes. For these studies we utilize a wide range of technologies composed of advanced imaging and mass spectrometry based technologies. The ultimate goal of the platelet biology program is to improve our understanding of platelet biology which allows for a better understanding of the mode of action and potential limitations of the current generation of platelet concentrates. In addition our studies also support the ex vivo generation of tailor-made platelets from induced pluripotent stem cells. The rare bleeding disorder program aims to further improve the current diagnosis of rare bleeding disorders and bleeding disorders of unknown cause employing “omics” based technologies. These studies are facilitated by the presence of recently developed platform for mass spectrometry based profiling of samples derived from patients with as yet undefined bleeding disorders.

 

Requirements
Specific Requirements

We anticipate the newly recruited scientists to contribute with their unique expertise, complementing our existing research portfolio. This includes inflammation and complement research, genetic and cellular approaches to correct and cure hematological disorders, as well as translational bioinformaticians with proven expertise to successfully integrate clinical and large “omics” based profiling data-sets in the area of transfusion medicine.

Additional Information
Benefits

We offer an international - academically oriented - research environment with state of-the-art equipment. You will have the opportunity to apply for internal and external funding to expand your group and if successful to apply for a permanent position as group leader.

• A challenging translational project in a multi-disciplinary and enthusiastic international team;
• Salary and conditions are conform CAO Sanquin;
• 8.33% end-of-year bonus; i.e. a thirteenth month in case of full-year employment;
• Partial reimbursement of travel costs;
• Pension plan with Pensioenfonds Zorg & Welzijn (PFZW);
• At fulltime employment (36 hours) 201 hours of leave per annum.

Beyond your own salary and ample bench fee, we offer a PhD student for the junior group leader and a PhD student and part-time technician for the mid career group leader. The early career fellowship will be funded for three years and the mid career fellowship for four years.

Selection process

If you are interested in one of these positions,  please apply by submitting  your extended CV before the 4th of March.

For the Early and Mid-Career fellowship we would like to ask to submit a brief statement on your research interest and the contribution you expect to be able to make towards our research program (max 2 pages).

Acquisition is not appreciated. Sanquin does not accept unsolicited help from agencies for vacancies. CV's sent (in any form whatsoever) by placement agencies to any Sanquin employee without a valid written assignment by HR Sanquin will be considered property of Sanquin for which no compensation is owed in any way.

Additional comments

If you are interested in one of these positions,  please apply by submitting  your extended CV before the 4th of March.

For the Early and Mid-Career fellowship we would like to ask to submit a brief statement on your research interest and the contribution you expect to be able to make towards our research program (max 2 pages).

More information can be obtained from the website (www.sanquin.org/research/research-vacancies ) or by sending an email to the Prof. dr. Jan Voorberg ([email protected] ) and Dr. Maartje van den Biggelaar ([email protected] ).

Acquisition is not appreciated. Sanquin does not accept unsolicited help from agencies for vacancies. CV's sent (in any form whatsoever) by placement agencies to any Sanquin employee without a valid written assignment by HR Sanquin will be considered property of Sanquin for which no compensation is owed in any way.

Website for additional job details

https://www.academictransfer.com/337426/

Work Location(s)

Number of offers available

1

Company/Institute

Sanquin Blood Supply Foundation (Sanquin)

Country

Netherlands

City

Amsterdam

Postal Code

1066 CX

Street

Plesmanlaan 125

Geofield

Where to apply

Website

https://www.academictransfer.com/en/337426/pi-postdocs-and-phd-student-gene-the…

Contact

City

Amsterdam

Website

http://www.sanquinresearch.nl/

Street

Plesmanlaan 125

Postal Code

1066 CX

STATUS: EXPIRED