PhD student ZonMW project

18 Apr 2024
Job Information

Organisation/Company

The Netherlands Cancer Institute

Research Field

Medical sciences
Physics
Other

Researcher Profile

Recognised Researcher (R2)
First Stage Researcher (R1)

Country

Netherlands

Application Deadline

17 May 2024 - 21:59 (UTC)

Type of Contract

Temporary

Job Status

Not Applicable

Hours Per Week

40.0

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

The labs of Alan Gerber (Amsterdam UMC – Location VUmc) and Fred van Leeuwen (Netherlands Cancer Institute, NKI) are teaming up to crack the code of gene regulation of tRNA genes. In a project supported by ZonMW, we will address how the hundreds of tRNA genes in our genome are regulated in their own unique way in response to cellular stress, during differentiation, and in cancer. Current data on tRNA genes and models for regulation of protein coding genes do not provide an explanation for the observed dynamics in the expression of tRNA genes. In this collaborative project, we will investigate the mechanisms of tRNA gene regulation using novel methods and technologies in human cells and budding yeast. We will take advantage of CRISPR-mediated approaches, high-throughput analysis of DNA regulatory regions, novel tRNA sequencing methods, and innovative strategies to decode ‘proteomes’ and ‘regulomes’ of tRNA genes.

Responsibilities

For this project, we are looking for two highly motivated and enthusiastic PhD students that will work together and with the two teams to unravel the mechanisms of tRNA gene regulation. One PhD student will be located in the Gerber lab (Amsterdam UMC, Department of Neurosurgery at the Cancer Center Amsterdam), the other in the Van Leeuwen lab at the Netherlands Cancer Institute (Division of Gene Regulation). The two institutes are only a 15 min bike ride apart.

More information about the labs and their research topics can be found here:
Gerber Lab: www.alangerberlab.com/
Van Leeuwen Lab: www.nki.nl/research/research-groups/fred-van-leeuwen/

Requirements
Specific Requirements

We are looking for ambitious PhD students with a strong background in molecular biology and with affinity for genomics and exploring new technologies. The candidates should be fluent in English, independent, detail-oriented and have a problem-solving attitude. Good communication skills and the ability to work in a team are essential.

Scientific environment

Located in Amsterdam, the Netherlands Cancer Institute (NKI) is an internationally renowned institute dedicated to fundamental, translational and clinical cancer research, and the only comprehensive cancer center in The Netherlands. It is a dynamic institute accommodating over 50 research groups and many excellent facilities, including imaging, flow cytometry, proteomics, genomics, screening, and many more. The laboratory is part of the highly collaborative Division of Gene Regulation with multiple groups of complementary expertise.

Additional Information
Benefits

Compensation

We offer a stimulating and interactive research environment, free use of all state-of-the-art facilities, and a competitive salary. The gross salary per month is € 3.355,- to € 4.073,- (salary PhD scale, according to the Collective Labour Agreement General Hospitals). In addition, you will receive 8,33% holiday pay and end-of-year bonus (8,33%). The appointment is for a period of four years. You will have the opportunity to follow high-quality courses offered by the Amsterdam OOA oncology graduate school.

Your travel expenses will be reimbursed at € 0,19 per km. Free parking at the Antoni van Leeuwenhoek is also part of the package. Personnel is stimulated to use public transport and bicycle and therefore we offer an interesting arrangement for bikers and/or discount on the NS-business card. 

Selection process

How to apply

 Applications should include your CV, a motivation letter, your transcripts and contact information of at least 2 references, and can be submitted via the application button.

The NKI values diversity and is committed to creating an inclusive work environment that stimulates the best in each individual. Applications of all individuals are welcomed regardless of age, ancestry, religion, disability, distance from the labor market, sexual orientation or gender identity.

Additional comments

How to apply

For further information and addresses visit our or contact Fred van Leeuwen  or Alan Gerber . Applications should include your CV, a motivation letter, your transcripts and contact information of at least 2 references, and can be submitted via the application button below.

The NKI values diversity and is committed to creating an inclusive work environment that stimulates the best in each individual. Applications of all individuals are welcomed regardless of age, ancestry, religion, disability, distance from the labor market, sexual orientation or gender identity.

Website for additional job details

https://www.academictransfer.com/340377/

Work Location(s)

Number of offers available

1

Company/Institute

The Netherlands Cancer Institute

Country

Netherlands

City

Amsterdam

Postal Code

1066 CX

Street

Plesmanlaan 121

Geofield

Where to apply

Website

https://www.academictransfer.com/en/340377/phd-student-zonmw-project/apply/#app…

Contact

City

Amsterdam

Website

https://www.avl.nl/

Street

Plesmanlaan 121

Postal Code

1066 CX

STATUS: EXPIRED