PhD student Nanobodies

28 Mar 2024
Job Information

Organisation/Company

Amsterdam UMC

Research Field

Physics

Researcher Profile

First Stage Researcher (R1)

Country

Netherlands

Application Deadline

18 Apr 2024 - 21:59 (UTC)

Type of Contract

Temporary

Job Status

Not Applicable

Hours Per Week

36.0

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Pathogens are recognized by a plethora of receptors on antigen presenting cells including C-type lectin receptors (CLRs) and sialic acid binding immunoglobulin-like lectin (Siglec) receptors. These receptors are important for pathogen infection and transmission, but also for the induction of immune responses. We will study the interaction between these two receptor types, how this determines immunity, and develop novel tools to block pathogen binding to CLRs and Siglec receptors. For this you will isolate, produce and characterize nanobodies that can bind CLRs and Siglec receptors and analyze their capacity to block pathogen infection and to target antigens to antigen presenting cells.

As a PhD student your main tasks and responsibilities are:

• Clone nanobodies that bind to different lectin and siglec receptors;
• Develop and produce multivalent nanobody molecules;
• Analyze the binding, uptake, routing, and induced signalling of nanobodies that bind to different receptors;
• Study the capacity of nanobodies to block infection by pathogens and develop and test nanobody based vaccines using human in vitro culture systems;
• Work closely with our collaborators on this project at Amsterdam UMC;
• Author manuscripts submitted to high quality journals and present at conferences.

Requirements
Specific Requirements

We are looking for a PhD student who has the following expertise and experience:

• You have a master degree (or equivalent) in molecular biology, chemistry, pharmaceutics, or biomedical sciences;
• You have experience with molecular biological techniques, protein expression systems, and/or cellular read outs;
• Excellent communications skills in English, both written and verbal;
• Good collaboration skills.

Hepatitis B vaccination is mandatory and will be provided by Amsterdam UMC.

Additional Information
Benefits

• We offer an initial contract for 12 months that can be extended (after evaluation) for another 36 months. We also provide you with the opportunity to follow further training and development.
• Salary scale: OIO € 2.901 - € 3.677 (based on a 36 hour week), depending on qualifications and experience.
• Additional benefits including an 8.3% end-of-year bonus and 8% holiday pay. Calculate your net salary here .
• Your pension is accrued at The Dutch Pension Fund for government and education employees (ABP). Amsterdam UMC contributes 70% of this scheme
• We reimburse 75% of your OV travel costs (commuting costs).

For more information about our employment conditions, please visit our website .

Additional comments

During the publication period, applications will be handled continuously. If the vacancy is filled, it will be closed prematurely.

If you have any questions about this position, please feel free to contact dr. J.M.M. den Haan, via +31(0)20 – 4448058.

For more information about the application procedure, please contact Chey Edwards, Recruitment Advisor, via [email protected] or via +316-21487245.

A reference check, screening and hiring test may be part of the procedure. Read here whether that applies to you. If you join us, we ask you for a VOG (Certificate of Good Conduct).

Internal candidates will be given priority over external candidates in case of equal suitability.

Acquisition in response to this vacancy is not appreciated.

Website for additional job details

https://www.academictransfer.com/339581/

Work Location(s)

Number of offers available

1

Company/Institute

Amsterdam UMC

Country

Netherlands

City

Amsterdam

Postal Code

1081HV

Street

De Boelelaan 1117

Geofield

Where to apply

Website

https://www.academictransfer.com/en/339581/phd-student-nanobodies/apply/#apply

Contact

City

Amsterdam Zuidoost

Website

https://www.amsterdamumc.org/

Street

Meibergdreef 9

Postal Code

1105 AZ

STATUS: EXPIRED