PhD position

13 Mar 2024
Job Information

Organisation/Company

University Medical Centre Groningen (UMCG)

Research Field

Medical sciences

Researcher Profile

Recognised Researcher (R2)
First Stage Researcher (R1)

Country

Netherlands

Application Deadline

28 Mar 2024 - 23:00 (UTC)

Type of Contract

Temporary

Job Status

Not Applicable

Hours Per Week

36.0

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Chimeric antigen receptor (CAR) T-cells, immune cells that are modified by CAR expression and as such are capable of killing tumor cells, constitute a therapy for patients with diffuse large B-cell lymphoma (DLBCL). CAR T-cell therapy has proven to be highly successful in patients with DLBCL when all other treatment options have failed, and has yielded overall response rates of ~50%. The Dept. of Hematology has established an academic Point-of-Care manufacturing program for CD19 CAR-T and is in the unique position to develop strategies to increase the efficacy of CAR-T therapy. The aim of this project is to perform in-depth metabolic profiling of CAR-T cells and identify key metabolic regulators that dictate resistance to therapy. Subsequently, rational design of next-gen CAR-Ts exploiting these metabolic pathways to augment potency will be developed and preclinically validated. This project is a collaboration between the Departments of Hematology and Pediatrics at the UMCG. We aim to improve the efficacy of CAR T-cells by modulating intracellular metabolic pathways.

Requirements
Specific Requirements

- You are a highly motivated candidate with an interest in immunotherapy and metabolism.
- You have an MSc in Biomedical Sciences, Pharmaceutical Sciences, Biochemistry or a related field.
- You have excellent oral and written communication skills in English.
- You have the ability to work in a research group.
- Experience in the fields of metabolism, immunology, and oncology is an advantage, as is experience with mouse models, flow cytometry, histology, cell biology, and molecular biology techniques.

The UMCG has a preventive Hepatitis B policy. The UMCG can provide you with the vaccination, should it be required for your position.
In case of specific professions a ‘Certificate of Good Conduct’ is required.

Additional Information
Benefits

We offer a full-time appointment (36 hours a week) for a period of three years. The preferred starting date is June 1st, 2024. Your salary will be a minimum of € 2.901,- gross per month in the first year and a maximum of € 3.677,- gross per month (PhD salary scale) in the final year, based on a full-time appointment. In addition, the UMCG will offer you 8% holiday pay, and 8.3% end-of-year bonus. The conditions of employment comply with the Collective Labour Agreement for Medical Centres (CAO-UMC).

Selection process

Marit Westerterp, [email protected] , telefoonnummer: 0031 50 361 6615

Additional comments

Marit Westerterp
0031 50 361 6615
[email protected]

Website for additional job details

https://www.academictransfer.com/338941/

Work Location(s)

Number of offers available

1

Company/Institute

University Medical Center Groningen (UMCG)

Country

Netherlands

City

Groningen

Postal Code

9713 GZ

Street

Hanzeplein 1

Geofield

Where to apply

Website

https://www.academictransfer.com/en/338941/phd-position/apply/#apply

Contact

City

Groningen

Website

http://www.werken.umcg.nl/

Street

Hanzeplein 1

Postal Code

9713 GZ

STATUS: EXPIRED