3 May 2024
Job Information
- Organisation/Company
Utrecht University- Research Field
Physics- Researcher Profile
First Stage Researcher (R1)- Country
Netherlands- Application Deadline
30 May 2024 - 21:59 (UTC)- Type of Contract
Permanent- Job Status
Not Applicable- Hours Per Week
40.0- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
Are you curious about how cells produce functional proteins? Do you want to push the envelope of applying single-molecule techniques to complex macromolecular systems? Join our single-molecule lab to study co-translational folding and chaperone function.
Your job
We are working at the interface of biochemistry, molecular biology and biophysics to follow the journey of nascent proteins toward their functional structures as they emerge from the ribosome. These mechanistic studies pave the way for targeted interventions against protein misfolding and perturbed protein homeostasis which are important for a number of aging-related diseases, including neurodegeneration, and several forms of cancer.
The research group of Professor Christian Kaiser , which just relocated from Johns Hopkins University to Utrecht, has established single-molecule optical tweezers assays for probing nascent protein folding on the ribosome. These studies have shown how the ribosome and molecular chaperones counter misfolding and help large, multi-domain proteins attain their functional structures. The group is now combining mechanical manipulation with single-molecule fluorescence detection. These in vitro studies are complemented by cellular assays. Collectively, the work is revealing fundamental principles of cellular protein biogenesis.
As a PhD in our group, you will:
- join a collaborative group working on projects around protein synthesis and folding;
- work in a stimulating scientific environment with top-notch instrumentation and infrastructure;
- master the use of optical tweezers with single-molecule fluorescence detection;
- utilise modern biochemical and molecular biology approaches for sample preparation;
- lead your own project around protein translation, molecular chaperone function and protein folding;
- collect, analyse and interpret single-molecule data and prepare your results for publications and presentations at national and international scientific meetings.
The position is embedded in the research group of Professor Christian Kaiser at the Bijvoet Centre for Biomolecular Research with state-of-the-art facilities, including brand-new molecular biology/biochemistry equipment and single-molecule instrumentation.
Requirements
Specific Requirements
We are looking for enthusiastic, highly motivated experimentalists who are eager to participate in our research.
Ideally, you meet several or all of the following criteria:
- a Master's degree in an experimental field related to Molecular Biology, Biochemistry or Biophysics (required);
- a passion for research in biochemistry or biophysics;
- basic molecular biology and biochemistry skills;
- an inclination toward quantitative analyses.
- good communication skills and an interest in working with people from different backgrounds.
Previous experience with single-molecule techniques and/or quantitative biophysical methods is welcome but not required.
We foster diversity and encourage applications from female candidates.
Additional Information
Benefits
We offer:
- a world class academic environment where English is the main language and where you receive academic training in our Molecular Life Sciences Programme;
- a supportive environment with a commitment to academic development and maintaining a healthy work-life balance;
- mentoring that emphasises personal, professional and scientific growth;
- a position for four years;
- a fulltime working week and a gross monthly salary between €2,770 and €3,539 in the case of full-time employment (salary scale P under the Collective Labour Agreement for Dutch Universities (CAO NU));
- 8% holiday pay and 8.3% year-end bonus;
- a pension scheme, partially paid parental leave and flexible terms of employment based on the CAO NU.
In addition to the terms of employment laid down in the CAO NU, Utrecht University has a number of schemes and facilities of its own for employees. This includes schemes facilitating professional development , leave schemes and schemes for sports and cultural activities , as well as discounts on software and other IT products. We also offer access to additional employee benefits through our Terms of Employment Options Model. In this way, we encourage our employees to continue to invest in their growth. For more information, please visit Working at Utrecht University .
Selection process
As Utrecht University, we want to be a home for everyone. We value staff with diverse backgrounds, perspectives and identities, including cultural, religious or ethnic background, gender, sexual orientation, disability or age. We strive to create a safe and inclusive environment in which everyone can flourish and contribute.
If you are enthusiastic about this position, just apply via the 'apply now' button! Please enclose:
- your letter of motivation;
- your curriculum vitae;
- the names, telephone numbers, and email addresses of at least two referees.
If this specific opportunity isn’t for you, but you know someone else who may be interested, please forward this vacancy to them.
Additional comments
If you have any questions that you’d like us to answer, please contact Dr Christian Kaiser at [email protected] .
Do you have a question about the application procedure? Please send an email to [email protected] .
- Website for additional job details
https://www.academictransfer.com/341133/
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Universiteit Utrecht
- Country
- Netherlands
- City
- Utrecht
- Postal Code
- 3584CH
- Street
- Padualaan 8
- Geofield
Where to apply
- Website
https://www.academictransfer.com/en/341133/phd-position-molecular-mechanisms-of…
Contact
- City
Utrecht- Website
http://www.uu.nl/- Street
Domplein 29- Postal Code
3512 JE
STATUS: EXPIRED
Similar Positions
-
Ph D Position: Molecular Mechanisms Of Protein Biogenesis, AcademicTransfer, Netherlands, 15 days ago
PhD Position: Molecular Mechanisms of Protein Biogenesis PhD Position: Molecular Mechanisms of Protein Biogenesis Published Deadline Location yesterday 30 May Utrecht Dissect protein synthesis, pr...
-
Ph D Student Position In New Functions Of Amyloid Fibers, Chalmers University of Technology, Sweden, 1 day ago
The Wittung-Stafshede research group is looking for a PhD student to explore newly-discovered catalytic activity of amyloid fibers. Major focus will be on alpha-synuclein involved in Parkinson's d...
-
Ph D Student: Transmembrane Protein Mimics For Communication Between Synthetic Cells, AMOLF, Netherlands, 19 days ago
As a PhD-student in our Physics of Cellular Interactions group headed by Dr. Kristina Ganzinger, you will apply state-of-the-art techniques to generate transmembrane protein mimics for communicati...
-
Ph D Position In Membrane Protein Structural Biology (65% Tv E13 Pay Scale) , Technical University of Munich, Germany, about 12 hours ago
15.05.2024, Wissenschaftliches Personal We are looking for a PhD student as a new team member at the Lab of Structural Membrane Biochemistry at the Technical University of Munich, working on the d...
-
Ph D Student In Structure Based Drug Design With Focus On Machine Learning (Ddls Research School), SciLifeLab, Sweden, about 22 hours ago
The Department of Cell and Molecular Biology is one of the most international, broad and distinguished molecular bioscience departments in Europe. The department comprises sju research programs wi...
-
Ph D Student In Structure Based Drug Design With Focus On Machine Learning, Uppsala University, Sweden, 1 day ago
Published: 2024-05-13 The Department of Cell and Molecular Biology is one of the most international, broad and distinguished molecular bioscience departments in Europe. The department comprises s...