PhD candidate for the role of compliment activation in neuropathies

29 Feb 2024
Job Information

Organisation/Company

University Medical Center Utrecht (UMC Utrecht)

Research Field

Medical sciences

Researcher Profile

First Stage Researcher (R1)

Country

Netherlands

Application Deadline

20 Mar 2024 - 22:59 (UTC)

Type of Contract

Temporary

Job Status

Not Applicable

Hours Per Week

36.0

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

The PhD student position is funded by the Prinses Beatrix Spierfonds and focuses on the role of complement in the development of immune-mediated neuropathies in collaboration with Erasmus MC and UMC Utrecht. We aim to unravel the overarching role of complement function in different immune-mediated neuropathies including multifocal motor neuropathy (MMN), Guillain-Barre syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP) to facilitate the development of rational and improved treatment strategies that target antibody and complement function.

Together with our UMC Utrecht-Argenx team, you will analyse the binding patterns of IgG and IgM anti-ganglioside antibodies from MMN, GBS, and CIDP patient sera to different neuronal cells, and investigate the role of complement activation in these diseases. Furthermore, in collaboration with the team at Erasmus MC, you will conduct an in-depth genetic analysis of single nucleotide polymorphisms associated with expression and function of complement proteins and regulators, and build a disease prediction model. You will write a PhD thesis (based on scientific publications) and follow courses at the Graduate school for Infection and Immunity.

Requirements
Specific Requirements

• You are a highly motivated, enthusiastic candidate with interest in (neuro)immunology, hands-on lab work, and affinity for data analysis.
• You have a master degree (or equivalent university degree) in (neuro)immunology, biomedical science, or a related discipline.
• You have excellent communication and organizational skills and you have the ability to work independently and in part of a team.
• You have a meticulous working method. You are proactive, responsible, and flexible. You also enjoy close collaboration with other team members.
• You enjoy working in the lab, but also have affinity with data analysis.

If you are interested in this position, please respond to this vacancy with a motivation letter and your CV (including past experience, publication record if applicable, and at least two references). We look forward to hearing from you.

Additional Information
Benefits

The maximum salary for this position (36 - 36 hours) is € 3.677,00 gross per month based on full-time employment.

In addition, we offer an annual benefit of 8.3%, holiday allowance, travel expenses and career opportunities. The terms of employment are in accordance with the Cao University Medical Centers (UMC).

Additional comments

Contact our colleague:
Anne van Aalst
06 11 23 86 60
[email protected]

Website for additional job details

https://www.academictransfer.com/338398/

Work Location(s)

Number of offers available

1

Company/Institute

UMC Utrecht

Country

Netherlands

City

Utrecht

Postal Code

3584CX

Street

Heidelberglaan 100

Geofield

Where to apply

Website

https://www.academictransfer.com/en/338398/phd-candidate-for-the-role-of-compli…

Contact

City

Utrecht

Website

http://www.umcutrecht.nl/

Street

Heidelberglaan 100

Postal Code

3584 CX

STATUS: EXPIRED