PhD Advanced thermo-chemotherapeutic treatment for breast cancer treatment

1 May 2024
Job Information

Organisation/Company

Amsterdam UMC

Research Field

Physics

Researcher Profile

First Stage Researcher (R1)

Country

Netherlands

Application Deadline

22 May 2024 - 21:59 (UTC)

Type of Contract

Permanent

Job Status

Not Applicable

Hours Per Week

36.0

Is the job funded through the EU Research Framework Programme?

Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

Breast cancer is the most common cancer for women worldwide. Not all patients respond to chemotherapy for the necessary downstaging to permit breast conserving surgery. The objective of the four year multicenter research project “Development of personalized MR-guided thermo-chemotherapy for breast conserving surgery” is to solve this problem by developing treatment technology for applying and monitoring effective novel personalized breast cancer treatments combining MR-guided local thermotherapy with ‘smart’ nano-chemotherapy.

This project is supported by a grant of the Netherlands Organization for Scientific Research NWO and performed at four Dutch centers. The work package at Amsterdam UMC aims to assist treatment delivery by creating a novel form of advanced treatment planning to predict the local drug distribution, and the temperature dependent effectiveness and cytotoxicity of these drugs. This is done in a digital model simulating the flow, heat and drug transport in a breast treated with thermo-chemotherapy. During treatments invasive and non-invasive thermometry will be combined with temperature simulations to reconstruct the true temperature distributions, which are combined with knowledge on temperature-dependent drug effectiveness to compute the combined effect of heat and chemotherapy. Goal is to establish strategies resulting in effective tumor eradication without unacceptable local and systemic side effects.

We are looking for a PhD student for four years with a physics background for designing and applying this digital model. Examples of a comparable form of modelling we developed for chemotherapy delivery during Hyperthermic IntraPeritoneal Chemotherapy are given in https://doi.org/10.1080/10717544.2020.1862364 and https://doi.org/10.1080/02656736.2020.1852324

A team of physicists, biologists and clinicians will advise on the work performed by the student.

The PhD student has a physics background and will create the novel form of advanced treatment planning to predict the local drug and temperature distribution, and ultimately the temperature dependent effectiveness and cytotoxicity of these drugs. This is involves developing a digital breast tumor model for simulating the flow, heat and drug transport in the breast during thermo-chemotherapy.

Work will involve development, adaptation and application of advanced computer models simulating various aspects of the thermo-chemotherapy breast cancer treatment, which is novel in the field.

Requirements
Specific Requirements

We are looking for a highly motivated candidate with a MSc degree in physics or a related background.

• The candidate preferably has practical experience with mathematical and numerical models in computer simulations and advanced programming in C/C++.
• The candidate should have good command of English.
• Excellent analytical and communicative skills and the ability to work within a multidisciplinary research group are essential.
• The research project should result in a PhD thesis.

Additional Information
Benefits

• A flying start to your career in scientific research.
• Plenty of room for personal development with a wide range of training & development of academic skills
• Working on large-scale and own research, with motivated colleagues
• A contract for 6 months with the prospect of extension for the duration.
• Salary scale: OIO: € 3.017tot € 3.824 bruto (based on a fulltime workweek), depending on qualifications and experience.
• Additional benefits including an 8.3% end-of-year bonus and 8% holiday pay. Calculate your net salary here .
• Your pension is accrued at BeFrank. A modern, understandeble en fair pension
• Excellent accessibility with public transportation and reimbursement of a large portion of your travel expenses. Additionally, we have plenty of parking spaces at the AMC location and a good bicycle scheme.

Additional comments

During the publication period, applications will be handled continuously. If the vacancy is filled, it will be closed prematurely.

For more information on the project please contact Hans Crezee via [email protected] or via 020-566 7963.

For more information about the application procedure, please contact Chey Edwards, Recruitment advisor, via 06-21487245or via [email protected] .

A reference check, screening and hiring test may be part of the procedure. Read here whether that applies to you. If you join us, we ask you for a VOG (Certificate of Good Conduct).

Internal candidates will be given priority over external candidates in case of equal suitability.

Acquisition in response to this vacancy is not appreciated.

Website for additional job details

https://www.academictransfer.com/341005/

Work Location(s)

Number of offers available

1

Company/Institute

Amsterdam UMC

Country

Netherlands

City

Amsterdam

Postal Code

1105AZ

Street

Meibergdreef 9

Geofield

Where to apply

Website

https://www.academictransfer.com/en/341005/phd-advanced-thermo-chemotherapeutic…

Contact

City

Amsterdam Zuidoost

Website

https://www.amsterdamumc.org/

Street

Meibergdreef 9

Postal Code

1105 AZ

STATUS: EXPIRED