Organ-on-Chip Platforms to model Inflammatory Arthritis
The position will be based within the Hoey and Kelly Labs at the Trinity Centre for Biomedical Engineering , Trinity College Dublin and will be part of the Materials for Health platform within the Advanced Materials and Bioengineering Research Centre (AMBER) centre.
Summary of project:
Arthritis is a leading cause of disability affecting up to 15% of the Irish population. 2% suffer from inflammatory arthritis (IA) such as rheumatoid arthritis (RA) and psoriatic arthritis (PsA). The cost of treating patients with IA in Ireland is ~€20,000/patient/year.
Drug development is a long, flawed process that can take 15 years and cost €2.3Billion per drug. 90% of drugs fail in clinical studies while 10% of drugs fail even after regulatory approval. A key determinant in this failed process is the lack of adequate lab-based models to test drug efficacy. Current human cell culture models are rudimentary and pre-clinical animal models don not accurately replicate the human response. Inflammatory Arthirits is debilitating disease and current therapeutics are severely limited. Therefore, the proposed project aims to develop microphysiological models of human bone, cartilage, and synovium which can be combined to form a Joint-on-Chip that can be used to better understand joint physiology and importantly pathophysiology. These models would represent innovative lab-based platforms for IA drug development and screening.
This project will combine expertise within the applicant’s team, along with collaborators in the School of Medicine , to develop new materials and cell culture platforms which will facilitate the recapitulation of human joint physiology in a dish.
The PhD student will be supported by a stipend of €18,000 + EU fees for 4 years.
How to apply:
CVs with the names and addresses of three referees should be e-mailed to:
Prof. David Hoey; E-mail: [email protected]
Positions will remain opened until filled but preferred start date is September 1 2022. Only short-listed applications will be acknowledged.
Similar Positions
-
Phd Position In Multiscale Modelling Of Endothelial Cell Monolayers In Health And Disease , University of Amsterdam, Netherlands, 5 days ago
Do you have a passion for life sciences, physiology, or medicine and are eager to employ computational science methods to study endothelial cells in the microcirculation? The Computational Science...
-
Ph D Student Position In Blood Cancer Research , University of Basel, Switzerland, 23 days ago
The Department of Biomedicine (DBM) is a joint effort between the University of Basel and the University Hospitals Basel. It unites basic and clinical scientists to advance our understanding of he...
-
Ph D Candidate In Molecular Nutrition , University of Oslo, Norway, 4 days ago
24th April 2024 Languages English English English PhD Candidate in Molecular Nutrition Apply for this job See advertisement Job description Applications are invited for a 3-year position in a Rese...
-
Ph D Student: Machine Learning In Plant Regulatory Genomics, VIB, Belgium, about 23 hours ago
Job description The Vandepoele research lab (Comparative Network Biology - https://www.vandepoelelab.be/ ) invites applications for a fully-funded PhD project for 1 year and extended with another...
-
Ph D Student Human Milk Extracellular Vesicles For Preterm Brain Development, AcademicTransfer, Netherlands, 23 days ago
PhD student - Human milk extracellular vesicles for preterm brain development PhD student - Human milk extracellular vesicles for preterm brain development Published Deadline Location today 25 Apr...
-
Ph D Position In Synthetic Biology, Wageningen University and Research Center, Netherlands, about 4 hours ago
Your job Have you ever thought about the questions, “What is life?” and “Can we create life-like systems?”. Are you excited about the prospect of building artificial entities, using basic molecula...