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configurations in human cells. Their importance is highlighted by the fact that mutations in genes coding for these complexes are found in more than 20% of all human cancers and are frequently causative
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are interested in DNA repair pathways and factors that ensure complete and accurate DNA replication in the face of DNA damage. On the other hand, we investigate the diverse signalling functions
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polymer formulations for the specific targeting of megakaryocytes which will then be loaded with mRNA of selected targets. Using primary cell cultures of murine megakaryocytes and human iPSC-derived
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genes on cell function and disease susceptibility. We are working in human iPSC generated models and in mice.Implications of selective escape from X-inactivation in neurodevelopmental disorders. If you
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model for the human autoimmune disease of the central nervous system (CNS) multiple sclerosis (MS). In EAE, dendritic cells (DCs) play an important role as they present a self-antigen to naive T cells and
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, regulates this process, though specifics remain unclear. The relevance of this process for human disease is also still unclear. Our project aims to decipher the ubiquitin code governing MDV-mediated quality
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muscle, brain, thymus, liver, placenta, and human liver. Furthermore, the modification is reversible by PAR glycohydrolases. We also discovered that DNA PARylation occurs on N1-deoxyadenosine, both in
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blocks of membranes. In the context of aging, specific lipids are potent modulators of lifespan. For example, monounsaturated fatty acids correlate with human longevity and extend lifespan in C. elegans
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number can reduce fitness and ultimately lead to organismal death. Sex chromosomes are an interesting exception, as female humans contain two X chromosomes, while males have only one X and one Y chromosome
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approaches. We encourage applications of highly motivated PhD candidates with a strong interest in structural biology, protein biochemistry, biophysics and structure-function relationship and a significant