Structural studies on molecular interactions of the Disrupted-in- schizphrenia (DISC1) protein
Job Offer Details
The molecular causes of schizophrenia are still unknown. Recently, based on several genetic studies, the disrupted-in-schizophrenia 1 (DISC1) protein has come into focus for investigating molecular mechanisms of schizophrenia and other mental diseases. Here, structural and quantitative investigations of DISC1 with its interacting centrosomal molecules NDEL1, NDE1, PDE4B and LIS1 are proposed. All proteins, or soluble representative fragments thereof, as well as mutant / polymorphic counterparts will be expressed in Escherichia coli. Structural studies will be attempted by NMR and crystallography for single and complexed proteins and complemented by binding studies with surface plasmon resonance. These investigations will yield insight into the stochiometry and regulation of the interactions in the DISC1/NDEL1/NDE1/LIS1/PDE4B complex, and, through structural determination of binding interfaces, open novel pharmacological targets for these diseases.
The ideal candidate will have a background in protein biochemistry and/or biophysical characterization of proteins. Basic knowledge and/or experience in crystallization and X-ray spectroscopy would be an advantage. A strong interest in structural biology is a prerequisite. We are looking for an enthusiastic and highly motivated individual with fluency in written and spoken English, an open mind for new approaches and a lot of team spirit. Workplace will be the University hospital Duesseldorf.
Language of the Doctoral Thesis
Requirements for Applicant
Subject Requirements (Qualification)
Application for BioStruct PhD scholarships is open to excellent candidates holding a MSc or Diploma degree in the fields of Biochemistry, Biology, Chemistry or related.
All BioStruct Applicants are expected to have achieved excellent results in their graduation and to show a high motivation and commitment for PhD studies in biostructural research applied to molecular medicine or biotechnology. To be considered applicants must have submitted a complete application prior to the Actual Submission Deadline and must be fluent in written and spoken English and/or German language.
http://www.uni- duesseldorf.de/home/Fakultaeten/math_nat/Graduiertenkollegs/biostruct/Ap plication/Scholarship#a3
Type of Persons
- Curriculum vitae
- Copy of university degree
- Letter of motivation
- see link
University / Organisation advertising the position
University / Organisation
Faculty / Institute
NRW Research School BioStruct
Supervisor of the Doctoral Thesis
Herr Prof. Dr. Carsten Korth
Postgraduate Scholarship In Assembly Of Transcriptional Complexes, University of Sydney, Australia, about 12 hours ago
Funding Body: ARC Title: Postgraduate Scholarship in Assembly of Transcriptional Complexes Research Areas: Sciences & Engineering Type Postgraduate Research Description: The scholarship is funded ...
Ph D Studentship – Regulation Of Kinetochore Function By Protein Phosphatases, The University of Southampton, United Kingdom, about 3 hours ago
Biological Sciences Research Location: Highfield Campus Closing Date: Monday 13 March 2017 Reference: 836617BJ PhD Studentship: Regulation of kinetochore function by protein phosphatases PhD Supe...
Ph D Studentship – An Interdisciplinary Pipeline For Progressing Cyclic Peptides Hits To Small Molecule Inhibitors., The University of Southampton, United Kingdom, about 3 hours ago
Chemistry Location: Highfield Campus Closing Date: Thursday 31 August 2017 Reference: 836517EB PhD Supervisors: Prof. Ali Tavassoli and Prof. Jon Essex Application Deadline: rolling, will appoint ...
Ph D Studentships: Biological Chemistry, University of Cambridge, United Kingdom, about 11 hours ago
The Department of Chemistry has available up to three PhD studentships in the field of biological chemistry to start in October 2017. The Department has a very strong biological chemistry section...
Ph D Scholarship In Protein Chemistry And Structural Biology, Technical University of Denmark, Denmark, about 12 hours ago
Apply no later than 24 February 2017 Apply for the job at DTU Chemistry by completing the following form. Apply online A 3-year PhD scholarship in Protein Chemistry, Structural and Computational B...
Ph D Position "Maximizing Photosynthetic Efficiency In Maize", Technische Universität München, Germany, about 11 hours ago
23.02.2017, Wissenschaftliches Personal The chair of plant breeding at the Technical University of Munich / TUM School of Life Sciences Weihenstephan invites applications for a PhD position TV-L E...