17 May 2024
Job Information
- Organisation/Company
Johannes Gutenberg University Mainz- Research Field
Biological sciences » Other- Researcher Profile
First Stage Researcher (R1)- Country
Germany- Application Deadline
23 Jun 2024 - 23:59 (Europe/Berlin)- Type of Contract
Temporary- Job Status
Full-time- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
Two PhD positions in Structural Biology/Protein Biochemistry are available in the research group of Prof. Eva Wolf at the Institute of Molecular Physiology (IMP) at Mainz University (Germany). Our research is focused on the structural, biochemical and biophysical analyses of proteins involved in circadian (day-time dependent) and circalunar (monthly) rhythms (e.g. Schmalen et al, Cell 2014; Pöhn, Krishnan et al, Nat Comm 2022; Vu, Behrmann et al, Nat Comm 2023). To elucidate the molecular mechanisms underlying circadian gene regulation and the synchronization of circadian/circalunar rhythms to sunlight and moonlight, the PhD students will apply a wide range of techniques, including cloning, recombinant protein expression (E.coli, insect cells), chromatographic FPLC-based protein purification, protein interaction studies (e.g. analytical SEC, native PAGE, fluorescence polarization, ITC, SPR, Pulldown/Mass Spectrometry), 3D-structural analyses (X-ray crystallography, Cryo-EM, AlphaFold predictions), UV/VIS- and CD spectroscopy, protein sequence analyses. Functional cell-based studies will be done in collaborations, potentially with own hands-on contributions.
Qualifications
- Strong interest in structural biology, protein biochemistry and structure-function relationship and a significant previous exposure to these research areas during the master education.
- Master degree in biochemistry, biotechnology, biophysics or related subjects.
- Practical experience with FPLC-based protein purification and some techniques involved in the biochemical, biophysical or 3D-structural analyses of purified proteins.
- Proficiency in English (spoken and written) is mandatory.
We offer
- Highly interdisciplinary and collaborative research projects integrating protein structure, molecular mechanisms and cellular function
- A stimulating, supportive, international and cooperative research environment
- Contracts (TV-L E13 65%), initially for 3 years
Contact for applications:
Please send your application including your CV, motivation letter, certificates, transcripts and contact details for two referees in a single pdf file to Eva Wolf ([email protected] ).
Prof. Dr. Eva Wolf
Structural Chronobiology
University Mainz (JGU)
Institute of Molecular Physiology (IMP)
Hanns-Dieter-Hüsch-Weg 17
55128 Mainz, Germany
https://chrono-wolf.biologie.uni-mainz.de
Requirements
- Research Field
- Biological sciences » Biology
- Education Level
- Master Degree or equivalent
Skills/Qualifications
- Strong interest in structural biology, protein biochemistry and structure-function relationship and a significant previous exposure to these research areas during the master education.
- Master degree in biochemistry, biotechnology, biophysics or related subjects.
- Practical experience with FPLC-based protein purification and some techniques involved in the biochemical, biophysical or 3D-structural analyses of purified proteins.
- Proficiency in English (spoken and written) is mandatory.
- Languages
- ENGLISH
- Level
- Excellent
- Research Field
- Biological sciences » Biology
Additional Information
Work Location(s)
- Number of offers available
- 2
- Company/Institute
- University Mainz
- Country
- Germany
- City
- Mainz
- Postal Code
- 55128
- Street
- Hanns-Dieter-Hüsch-Weg 17
- Geofield
Where to apply
[email protected]
Contact
- State/Province
Deutschland- City
Mainz- Website
https://chrono-wolf.biologie.uni-mainz.de
[email protected]
STATUS: EXPIRED
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