1 PhD Position in �Role of microRNAs in Endothelial- and SMC-Function�
Job Offer Details
MicroRNAs (miRNAs) comprise a novel class of endogenous, small, noncoding RNAs that negatively regulate gene expression via degradation or translational inhibition of their target mRNAs.
Accumulating evidence emerges that the deregulation of miRNA synthesis and expression often comprises an initial step in disease development. However, the role of impaired miRNA processing during the development of vascular diseases like atherosclerosis or post-angioplasty restenosis has not been investigated so far and may offer an interesting approach for the prevention or treatment of these diseases. The current project is aimed to first characterize differentially regulated miRNAs in different in vivomodels of vascular diseases. By knock down or overexpression studies their impact on EC or SMC function (proliferation, migration, apoptosis, differentiation) will be assessed in vitro. Microarray analysis and proteomic screenings combined with in silico analysis will be utilized to identify target mRNAs which will be further validated by luciferase assays and characterized for their impact on the observed cellular function. Additionally, the regulatory mechanisms of the expression of these miRNAs will be further evaluated by identifying the responsible stimuli and upstream signaling cascades. Further in vivo experiments, in which selected miRNAs will be overexpressed or knocked down will reveal their impact on the development of vascular diseases and therefore their potential for therapeutic interventions.
Language of the Doctoral Thesis
Requirements for Applicant
Subject Requirements (Qualification)
Type of Persons
- Curriculum vitae
- Copy of university degree
- Letter of motivation
- Language Certificate English
University / Organisation advertising the position
University / Organisation
Faculty / Institute
International Giessen Graduate School for the Life Sciences (GGL)
Supervisor of the Doctoral Thesis
Herr Prof. Dr. Daniel Sedding
Ph D Position In Process Chemometrics With Focus On Green Technology, Umeå University, Sweden, 10 days ago
We are looking for a highly motivated candidate willing to contribute to our on-going efforts in developing innovative multivariate techniques for smart process systems using model based approaches...
Ph D Studentships In Computer Vision And Machine Learning, A*STAR/NUS/NTU, Singapore, 20 days ago
The Machine Learning For Bioimage Analysis group, BII, A*STAR of Singapore is looking for outstanding PhD students to join us.Our research group works on the exciting research topics of machi...
Design Led Approach To Drive Sector Wide Innovation And Impact Ph D Scholarship (External), University of Technology Sydney, Australia, 8 days ago
In a recent collaborative design-led innovation program between CSIRO and UTS it was found that design-led innovation (DLI) does add value to firms, at least at an individual level in terms of cha...
Ph D Student Department Of Analytical Chemistry, Ghent University, Belgium, 14 days ago
Job posted by Academic Positions (17/06/2016 10.34) Marie Curie Actions. More 'HR Excellence in Research' logo awarded to institutions actively implementing the European Charter and Code for Resea...
Ph D Student, Ghent University, Netherlands, 13 days ago
Job description Full-time 4-year PhD position (grant) at the Atomic & Mass Spectrometry – A&MS research unit of the Department of Analytical Chemistry (WE08), Faculty of Sciences, Ghent University...
Ph D Candidate: Suppression Of Voice By Colleagues 1,0 Fte, Radboud University, Netherlands, 9 days ago
At Radboud University, we do research and teach programmes covering the full width of the academic spectrum. We do this on a green, modern campus with state-of-the-art facilities. The atmosphere o...