1 PhD Position in �Role of microRNAs in Endothelial- and SMC-Function�
Job Offer Details
MicroRNAs (miRNAs) comprise a novel class of endogenous, small, noncoding RNAs that negatively regulate gene expression via degradation or translational inhibition of their target mRNAs.
Accumulating evidence emerges that the deregulation of miRNA synthesis and expression often comprises an initial step in disease development. However, the role of impaired miRNA processing during the development of vascular diseases like atherosclerosis or post-angioplasty restenosis has not been investigated so far and may offer an interesting approach for the prevention or treatment of these diseases. The current project is aimed to first characterize differentially regulated miRNAs in different in vivomodels of vascular diseases. By knock down or overexpression studies their impact on EC or SMC function (proliferation, migration, apoptosis, differentiation) will be assessed in vitro. Microarray analysis and proteomic screenings combined with in silico analysis will be utilized to identify target mRNAs which will be further validated by luciferase assays and characterized for their impact on the observed cellular function. Additionally, the regulatory mechanisms of the expression of these miRNAs will be further evaluated by identifying the responsible stimuli and upstream signaling cascades. Further in vivo experiments, in which selected miRNAs will be overexpressed or knocked down will reveal their impact on the development of vascular diseases and therefore their potential for therapeutic interventions.
Language of the Doctoral Thesis
Requirements for Applicant
Subject Requirements (Qualification)
Type of Persons
- Curriculum vitae
- Copy of university degree
- Letter of motivation
- Language Certificate English
University / Organisation advertising the position
University / Organisation
Faculty / Institute
International Giessen Graduate School for the Life Sciences (GGL)
Supervisor of the Doctoral Thesis
Herr Prof. Dr. Daniel Sedding
Ph D Student In Advanced Surface Electromechanics, Institut Català de Nanociència i Nanotecnologia, Spain, 16 days ago
ICN2 is a renowned research centre. Its research lines focus on the newly discovered physical and chemical properties that arise from the fascinating behaviour of matter at the nanoscale.The Instit...
Bbsrc Ph D Studentship: Regulation And Function Of Chromatin Domains, University of Cambridge, United Kingdom, 5 days ago
A BBSRC DTP targeted PhD studentship is available to study the regulation and function of chromatin domains in the laboratory of Professor Julie Ahringer. Eukaryotic genomes are organized into chr...
Ph D Studentship: Ultrasonic Invention To Effectively Control Dental Plaque Biofilms, The University of Southampton, United Kingdom, 16 days ago
This project (sponsored by GlaxoSmithKline, Innovate UK and BBSRC) pays £3000 above the usual PhD stipend. The project will revolutionize the ability of mm-thick streams of cold water to clean, in...
Ph D Scholarship In Damage Tolerance Of Sandwich Structures In Naval Vessels Operating In Arctic Regions, Technical University of Denmark, Denmark, 8 days ago
Apply no later than 1 January 2017 Apply for the job at DTU Mechanical Eng by completing the following form. Apply online The Department of Mechanical Engineering, Section of Solid Mechanics at th...
Open Learning Faculty Member (Web) Hrmn 4831: Total Rewards , Thompson Rivers University, Canada, 23 days ago
Application Restrictions Open to both Internal and external Job Type Open Learning Faculty Member Posting In effect from 6/12/2016 Closing Application Date 20/12/2016 OLFM Type Regular Continuous ...
Ph D Studentship: The Analysis Of Urban Growth And Surface Permeability Informed By Earth Observation Data, University of Surrey, United Kingdom, 10 days ago
View All Vacancies Department Civil and Environmental Engineering Location: Other Post Type: Full Time Advert Placed: Tuesday 29 November 2016 Closing Date: Monday 30 January 2017 Reference: ...