1 PhD Position in �Role of microRNAs in Endothelial- and SMC-Function�
Job Offer Details
MicroRNAs (miRNAs) comprise a novel class of endogenous, small, noncoding RNAs that negatively regulate gene expression via degradation or translational inhibition of their target mRNAs.
Accumulating evidence emerges that the deregulation of miRNA synthesis and expression often comprises an initial step in disease development. However, the role of impaired miRNA processing during the development of vascular diseases like atherosclerosis or post-angioplasty restenosis has not been investigated so far and may offer an interesting approach for the prevention or treatment of these diseases. The current project is aimed to first characterize differentially regulated miRNAs in different in vivomodels of vascular diseases. By knock down or overexpression studies their impact on EC or SMC function (proliferation, migration, apoptosis, differentiation) will be assessed in vitro. Microarray analysis and proteomic screenings combined with in silico analysis will be utilized to identify target mRNAs which will be further validated by luciferase assays and characterized for their impact on the observed cellular function. Additionally, the regulatory mechanisms of the expression of these miRNAs will be further evaluated by identifying the responsible stimuli and upstream signaling cascades. Further in vivo experiments, in which selected miRNAs will be overexpressed or knocked down will reveal their impact on the development of vascular diseases and therefore their potential for therapeutic interventions.
Language of the Doctoral Thesis
Requirements for Applicant
Subject Requirements (Qualification)
Type of Persons
- Curriculum vitae
- Copy of university degree
- Letter of motivation
- Language Certificate English
University / Organisation advertising the position
University / Organisation
Faculty / Institute
International Giessen Graduate School for the Life Sciences (GGL)
Supervisor of the Doctoral Thesis
Herr Prof. Dr. Daniel Sedding
Computational Biologist Position , LabEx HepSYS, France, 6 days ago
Job posted by Academic Positions (26/03/2015 10.27) Marie Curie Actions. More 'HR Excellence in Research' logo awarded to institutions actively implementing the European Charter and Code for Resea...
Ph D Studentship To Start In October 2015, The Open University, United Kingdom, 15 days ago
This three-year research studentship is partly externally funded and partly funded by the Faculty of Science at The Open University and provide a maintenance grant of £14, 057 per year (2015 rate)...
Ph D Position In Molecular Biology: Rna Editing In Skeletal Muscle During Development, Karlsruhe Institute of Technology (KIT) - Helmholtz Association, Germany, 29 days ago
Marie Curie Actions Co-fund. More Marie Curie Actions. More European Research Council. More 'HR Excellence in Research' logo awarded to institutions actively implementing the European Charter and ...
Ph D Scholarship: Mass Spectrometry Imaging (Msi) Based Investigation Of Interdependent Agent Host Responses In Veterinary Animals, Technical University of Denmark, Denmark, 16 days ago
Apply no later than 30 March 2015 Apply for the job at DTU Vet by completing the following form. Apply online DTU Veterinary Institute (DTU Vet) is seeking a PhD student for a 3-year project on Ma...
Ph D Scholarship Opportunity: Developmental Biology And Genetics, Monash University, Australia, 13 days ago
Job No. 534023 Faculty / Portfolio: Faculty of Medicine, Nursing and Health Sciences Central Clinical School Location: AMREP (Alfred Hospital), Monash University Supervisors: Dr. Sebastian Dworkin...
Ph D Scholarship: The Importance Of The Immunological Competence Of The Mink Bitch During The Perinatal And Suckling Period For The Development Of 'wet Kit Syndrome', Technical University of Denmark, Denmark, 16 days ago
Apply no later than 30 March 2015 Apply for the job at DTU Vet by completing the following form. Apply online DTU Veterinary Institute (DTU Vet) is seeking a PhD student for a 3-year project on th...