1 PhD Position in �Role of microRNAs in Endothelial- and SMC-Function�
Job Offer Details
MicroRNAs (miRNAs) comprise a novel class of endogenous, small, noncoding RNAs that negatively regulate gene expression via degradation or translational inhibition of their target mRNAs.
Accumulating evidence emerges that the deregulation of miRNA synthesis and expression often comprises an initial step in disease development. However, the role of impaired miRNA processing during the development of vascular diseases like atherosclerosis or post-angioplasty restenosis has not been investigated so far and may offer an interesting approach for the prevention or treatment of these diseases. The current project is aimed to first characterize differentially regulated miRNAs in different in vivomodels of vascular diseases. By knock down or overexpression studies their impact on EC or SMC function (proliferation, migration, apoptosis, differentiation) will be assessed in vitro. Microarray analysis and proteomic screenings combined with in silico analysis will be utilized to identify target mRNAs which will be further validated by luciferase assays and characterized for their impact on the observed cellular function. Additionally, the regulatory mechanisms of the expression of these miRNAs will be further evaluated by identifying the responsible stimuli and upstream signaling cascades. Further in vivo experiments, in which selected miRNAs will be overexpressed or knocked down will reveal their impact on the development of vascular diseases and therefore their potential for therapeutic interventions.
Language of the Doctoral Thesis
Requirements for Applicant
Subject Requirements (Qualification)
Type of Persons
- Curriculum vitae
- Copy of university degree
- Letter of motivation
- Language Certificate English
University / Organisation advertising the position
University / Organisation
Faculty / Institute
International Giessen Graduate School for the Life Sciences (GGL)
Supervisor of the Doctoral Thesis
Herr Prof. Dr. Daniel Sedding
Computational Biologist Position , LabEx HepSYS, France, 26 days ago
Job posted by Academic Positions (26/03/2015 10.27) Marie Curie Actions. More 'HR Excellence in Research' logo awarded to institutions actively implementing the European Charter and Code for Resea...
Ph D Position In Molecular Biology The Role Of Dna Damage In The Pathogenesis Of Nitrate Tolerance, International PhD Programme “Dynamics of Gene Regulation, Epigenetics and DNA Damage Response”, Germany, 14 days ago
Job posted by International PhD Programme “Dynamics of Gene Regulation, Epigenetics and DNA Damage Response” (07/04/2015 12.03) Marie Curie Actions. More 'HR Excellence in Research' logo awarded t...
Tu Delft Architecture B&T Ph D Call Info, Delft University of Technology, The Netherlands, 11 days ago
BORDERS&TERRITORIESOpen Invitation for PhD Dissertation Proposalssession #05 Thursday 04 June 2015INTRODUCTIONUnder the auspices of the Graduate School of the Faculty of Architecture and t...
Ph D Scholar Of Department Of Aquaculture Management And Technology, Vidyasager University, India, 14 days ago
PhD Scholar field of fish management, ORGANIC aquaculture.Other activity -Aquatic Ecology, toxicology,marine aquaculture, organic aquaculture,wast water management (RAS),climate change all type of ...
Ph D Position At The Institute Of Organic Chemistry, University Of Erlangen Nürnberg, University of Erlangen-Nürnberg, Germany, 11 days ago
A PhD position at the Institute of Organic Chemistry, University of Erlangen-Nürnberg, Erlangen, Germany in the group led by Dr. Konstantin Amsharov is available for a period of 36 months. The rese...
Ph D Position In Molecular Biology Innate Lymphoid Cells, International PhD Programme “Dynamics of Gene Regulation, Epigenetics and DNA Damage Response”, Germany, 10 days ago
Job posted by International PhD Programme “Dynamics of Gene Regulation, Epigenetics and DNA Damage Response” (10/04/2015 09.30) Marie Curie Actions. More 'HR Excellence in Research' logo awarded t...