1 PhD Position in �Role of microRNAs in Endothelial- and SMC-Function�
Job Offer Details
MicroRNAs (miRNAs) comprise a novel class of endogenous, small, noncoding RNAs that negatively regulate gene expression via degradation or translational inhibition of their target mRNAs.
Accumulating evidence emerges that the deregulation of miRNA synthesis and expression often comprises an initial step in disease development. However, the role of impaired miRNA processing during the development of vascular diseases like atherosclerosis or post-angioplasty restenosis has not been investigated so far and may offer an interesting approach for the prevention or treatment of these diseases. The current project is aimed to first characterize differentially regulated miRNAs in different in vivomodels of vascular diseases. By knock down or overexpression studies their impact on EC or SMC function (proliferation, migration, apoptosis, differentiation) will be assessed in vitro. Microarray analysis and proteomic screenings combined with in silico analysis will be utilized to identify target mRNAs which will be further validated by luciferase assays and characterized for their impact on the observed cellular function. Additionally, the regulatory mechanisms of the expression of these miRNAs will be further evaluated by identifying the responsible stimuli and upstream signaling cascades. Further in vivo experiments, in which selected miRNAs will be overexpressed or knocked down will reveal their impact on the development of vascular diseases and therefore their potential for therapeutic interventions.
Language of the Doctoral Thesis
Requirements for Applicant
Subject Requirements (Qualification)
Type of Persons
- Curriculum vitae
- Copy of university degree
- Letter of motivation
- Language Certificate English
University / Organisation advertising the position
University / Organisation
Faculty / Institute
International Giessen Graduate School for the Life Sciences (GGL)
Supervisor of the Doctoral Thesis
Herr Prof. Dr. Daniel Sedding
Ph D: Multimodal Imaging Of The Heart Muscle Analysis And Visualization To Aided Diagnosis, Laboratoire d'électronique et informatique de l'image (Le2i) UMR CNRS 6306 - Université de Bourgogne, France, 29 days ago
Doctoral School Engineering Science and Microtechnology (SPIM)University of Burgundy (UB) - Electronic and image processing laboratory (Le2i)Thesis proposal in medical imagingDirector: Professor Ta...
Molecular Virology Ph D Student, Department of Biotechnology University of Rijeka, Croatia, 6 days ago
Job posted by Department of Biotechnology University of Rijeka (01/07/2015 14.22) Marie Curie Actions. More 'HR Excellence in Research' logo awarded to institutions actively implementing the Europ...
3 Three Year Funded Ph D Positions In Cognitive, Social And Affective Neuroscience, , Italy, 16 days ago
Rome, 19 June 2015 Call for Application for Prospective Ph.D. StudentsCode: 16167 - Psychology and Social NeuroscienceResearch curriculum in Cognitive Social and Affective Neurosciences ...
Doctoral (Ph D) Student Position In Motor Neuron Diseases (Kid Funding), Karolinska Institutet, Sweden, 4 days ago
Research groups at the Department of Neuroscience study different aspects of the function of the normal nervous system, as well as disturbances, injuries and diseases affecting the nervous system...
Ph D Position In Imaging Disease Connectome, The University of Queensland, Australia, 9 days ago
Apply now Job no:497609 Area:Queensland Brain Institute Salary (FTE):APA Scholarship NON-BANDED ($25,849.00 - $25,849.00) Work type:Full Time - Scholarship Location: St Lucia Queensland Brain Inst...
Ph D Candidate For Neuroscience 1,0 Fte, Radboud University, Netherlands, 6 days ago
At Radboud University, we do research and teach programmes covering the full width of the academic spectrum. We do this on a green, modern campus with state-of-the-art facilities. The atmosphere o...