1 PhD Position in �Optimal design considerations for batch diafiltration�
Job Offer Details
Membrane technology has become a dignified separation technology over the last decades. Numerous membrane-based separation processes established and run, to various degrees, often at least effectively. Membrane filtration processes are usually designed to fulfill dual objectives: (i) to separate certain solutes from the process liquor and (ii) to concentrate the purified solution in order to obtain a final product. In this project we aim at studying diafiltration processes that meet these simultaneous objectives. Diafiltration is a membrane-assisted process that is designed to achieve the twin-objectives of concentrating and purifying a multi-solute system according to a specific wash-water utilization strategy. Diafiltration problems arise in many applications in the food and beverage, chemical, pharmaceutical, and biotechnology sector. We can distinguish between discontinuous (i.e. batch) and continuous diafiltration. This research addresses the issue of developing efficient membrane filtration schemes for batch and continuous diafiltration processes and, in particular, deals with industrially-relevant multi-component process streams. Within the frame of this project, the most relevant issues to be addressed are: (i) to provide robust data-driven models for the diafiltration of multi- component systems where the permeation of individual components are highly interrelated, (ii) to determine optimal control of batch diafiltration by employing optimal control theory and dynamic optimization methods, and (iii) to develop a mathematical framework for the design of continuous co- and counter-current diafiltration processes. The experimental investigations focus on various industrially-relevant problems, for instance, desalination of whey with nanofiltration, concentration and purification of virus suspensions, and ultrafiltration of human serum albumin.
Language of the Doctoral Thesis
Requirements for Applicant
Subject Requirements (Qualification)
Type of Persons
- Curriculum vitae
- Copy of university degree
- Letter of motivation
- Language Certificate English
University / Organisation advertising the position
University / Organisation
Faculty / Institute
International Giessen Graduate School for the Life Sciences (GGL)
Supervisor of the Doctoral Thesis
Herr Prof. Dr. Peter Czermak
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