1 Doctoral Position in Matrix Biology
Job Offer Details
A PhD student position is available at the Center for Biochemistry, Medical Faculty of the University of Cologne. The research topic will be focused on studying disease mechanisms caused by mutations in the Fibrillin genes (FBN1, FBN2). Human mutations in the Fibrillin genes lead to various congenital disorders, the so called fibrillinopathies including Marfan Syndrome with manifestations in the musculoskeletal, ocular or dermal system. Since breakthrough advances point to dysregulated TGFbeta as a key aspect in Marfan Syndrome, specific emphasis will be on investigating how the extracellular Fibrillin network regulates growth factors of the TGFbeta superfamily. This will be achieved by biochemical means in vitro and in a newly generated Fibrillin-1 deficient mouse model in vivo.
The successful candidate will join a young, ambitious research team with national and international partners embedded within a highly interactive and well equipped environment (CMMC: Center for Molecular Medicine Cologne; CECAD: Cluster of Excellence in Cellular Stress Responses in Ageing-Associated Diseases). Excellent research and training conditions and the opportunity to learn a broad range of methods while working on a topic highly relevant for translational medicine and bioengineering will be offered. Equipment and funding for consumables is provided.
Language of the Doctoral Thesis
Requirements for Applicant
Subject Requirements (Qualification)
The ideal candidate is a highly motivated, team-oriented student with strong interest in disease pathogenesis and preferably with a background in biochemistry, cell or molecular biology. Experience with animal experimentation, microscopy or molecular biology techniques (e.g. cloning, overexpression, protein purification, site-directed mutagenesis) is advantageous. Candidates should hold a diploma or master?s degree in biochemistry, biology, or related areas.
Type of Persons
- Curriculum vitae
- Copy of university degree
University / Organisation advertising the position
University / Organisation
Universit�t zu K�ln
Faculty / Institute
Center of Biochemistry
Supervisor of the Doctoral Thesis
Herr Dr. Gerhard Sengle
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