16 Mar 2024
Job Information
- Organisation/Company
CNRS- Department
Centre de Recherche Paul Pascal- Research Field
Chemistry » Physical chemistry
Physics » Chemical physics
Physics » Biophysics- Researcher Profile
First Stage Researcher (R1)- Country
France- Application Deadline
5 Apr 2024 - 23:59 (UTC)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
35- Offer Starting Date
1 Sep 2024- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
Key-words: Active Brownian matter – Self-propelled particles– Light powered microswimmers – Filamentous viruses.
This PhD project is mainly experimental with multiple collaborations providing varied supports and expertises. It is fundamentally interdisciplinary, combining soft matter physics, physico-chemistry, as well as the production and manipulation of biological objects. The candidates should be in possession of, or expect to attain, a Master's in a relevant discipline (Physical Chemistry, Materials science, Physics, Nanoscience, etc). Good skills in written and oral communication in English are important.
Mimicking the properties of life in artificial particles is a current research frontier between biophysics and synthetic biology. Among these properties, reproducing motility and directional swimming is major for understanding the individual and collective behavior of their more complex natural counterparts, while having strong potential for developing advanced therapies. One of the most efficient mechanisms of Brownian particle self-propulsion is based on self-phoretic swimmers that propel themselves by generating a local gradient of concentration, temperature, etc through asymmetric surface properties (Janus particles). These gradients induce surface flows that lead to directed motion. In this PhD project, we aim at designing and developing a new generation of self-propelled particles, either chemically powered by enzymatic decomposition of glucose fuel or light driven by self-thermophoresis, and asymmetrically functionalized with filamentous bacteriophages in order to improve their directional swimming efficiency. The spatiotemporal organization of these fuel and light powered nanoparticles will be studied at the single particle level thanks to advanced optical microscopy techniques in order to characterize their dynamical behavior and to understand individual and collective effects in simple and complex fluids. While addressing relevant fundamental questions, the objective of the project is to establish a proof of concept for the design of self-propelled artificial protocells capable of demonstrating efficient motility, allowing in the long term to solve some drug delivery challenges.
Requirements
- Research Field
- Chemistry
- Education Level
- PhD or equivalent
- Research Field
- Physics
- Education Level
- PhD or equivalent
- Research Field
- Physics
- Education Level
- PhD or equivalent
- Languages
- FRENCH
- Level
- Basic
- Research Field
- Chemistry » Physical chemistry
- Years of Research Experience
- None
- Research Field
- Physics » Chemical physics
- Years of Research Experience
- None
- Research Field
- Physics » Biophysics
- Years of Research Experience
- None
Additional Information
Additional comments
Applications should include a CV, contacts of two referees and a brief statement of interests for this specific PhD research project. Please send your application or any inquiry, to [email protected]
- Website for additional job details
https://emploi.cnrs.fr/Offres/Doctorant/UMR5031-ERIGRE-006/Default.aspx
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Centre de Recherche Paul Pascal
- Country
- France
- City
- PESSAC
- Geofield
Where to apply
- Website
https://emploi.cnrs.fr/Candidat/Offre/UMR5031-ERIGRE-006/Candidater.aspx
Contact
- City
PESSAC- Website
http://www.crpp-bordeaux.cnrs.fr/
STATUS: EXPIRED