PhD fellowship in biophysics: Learning from deep vein rheology to better approach the pathophysiology of Venous Thrombosis
8 Apr 2024
Job Information
- Organisation/Company
Aix Marseille University, Interdisciplinary Center of Nanoscience of Marseille (CINaM)- Department
SSP/Biomedical engineering- Research Field
Physics » Biophysics- Researcher Profile
First Stage Researcher (R1)- Country
France- Application Deadline
17 May 2024 - 00:00 (Europe/Paris)- Type of Contract
Temporary- Job Status
Full-time- Offer Starting Date
1 Oct 2024- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
PhD fellowship in Aix Marseille University in between two doctoral schools: "Physics and Science of Matter " and "Biology".
The PhD subject:
Venous Thrombosis (VT) is the third leading cause of cardiovascular death in industrialized countries and a major health concern. The VT pathophysiology is still poorly understood but we know that VT is a multifactorial disease in which inflammation/hypercoagulability, endothelial injury/dysfunction, and flow disorders (such as blood stagnancy) are critical components and predisposing risk factors.
This thesis aims to explore the role of blood rheology in thrombus formation around the venous valve present in deep veins. Focusing on specific aspects of blood flow around venous valves, the study aims to develop a finite element model to better understand and predict the mechanisms underlying thrombus formation.
Task description:
1. You will use a commercial finite element software Comsol to create a fluid-structure interaction model of the venous valves and the pulsatile blood flow.
2. You will validate experimentally the obtained numerical simulations
3. You will test the cellular interactions of platelets/neutrophils in flow chamber with valves.
About us
CINaM and C2VN are two labs with complimentary skills in physics and vascular biology. Both laboratories belong to Aix Marseille University. The University Campus proposes all sport facilities and modern library for students.
The team is young and dynamic, international students are welcome!
About you
- You have a master or equivalent degree in biophysics or in physics but you would like to learn more about biology.
- You are skilled in finite element modeling and fluid dynamics
- You are fluent in written and spoken English (you are not required to speak French)
- You are able to work autonomously in an interdisciplinary environment.
Requirements
- Research Field
- Physics » Biophysics
- Education Level
- Master Degree or equivalent
Skills/Qualifications
he/she has a solid interdisciplinary background combining physics, biology, fluid mechanics and finite element modeling.
Master degree or equivalent diploma in biophysics, biomedical engineering or biomechanics
- Languages
- ENGLISH
- Level
- Excellent
- Languages
- FRENCH
- Level
- Basic
Additional Information
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Aix Marseille University, Interdisciplinary Center of Nanoscience of Marseille (CINaM)
- Country
- France
- City
- Marseille
- Postal Code
- 13288
- Street
- campus Luminy and La Timone
Where to apply
[email protected]
Contact
- City
Marseille- Website
https://www.univ-amu.fr/- Street
Campus de Luminy- Postal Code
Case 913 13288 MARSE
STATUS: EXPIRED