PhD scholarship in Cancer Bioinformatics – DTU Health Tech

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PhD scholarship in Cancer Bioinformatics – DTU Health Tech
Kgs. Lyngby, Denmark
Job Description

DTU Health Tech is seeking one PhD Student for the Cancer System Biology group headed by Associate Professor Elena Papaleo, to work in collaboration with clinicians focusing on childhood cancer and rare diseases at Rigshospitalet. The collaboration further extends to clinical and research groups in Lund, Sweden, and Abzu, as a part of the EU inter-regional cooperation effort ELEGANT North (Exploring Leukemia: Education Genetics and Technology; New Option for Rare diseases Towards Health).
The Cancer System Biology group is part of the Section of Bioinformatics at the department that houses different internationally-diverse research group in an open collaborative atmosphere, and promoting synergy with other research groups at DTU.
The Section has access to Computerome2, a large life-science dedicated supercomputer and co-develops the bioinformatic environment on this platform. The spoken language is English and there is a strong emphasis on internationalization of the research environment.
The PhD student will enroll in the PhD School of Health and Technology at DTU.
Responsibilities and qualifications
A huge amount of data has been rapidly gathered on children with cancers in publicly available repositories and Scandinavian Hospitals. This includes data on germline whole genome sequencing, tumor mutations and gene expression, along with information on many clinical variables. The group has also the possibility to collaborate with cancer cellular biologists to carry out experimental validation of the predictions from bioinformatic analyses using cellular models or in-vitro assays. The student will be offered the possibility to validate the predictions experimentally in one of the projects carried out during the PhD.
We seek for researchers in bioinformatics interested in integrating genomic analyses with structure-based methods to advance our research from the molecular basis of the disease to translational oncology and precision medicine and contribute to shape and design a data warehouse where to share data and results across different countries.
The current recruitment will address, among others, the following areas: 

• Prioritization of genomics variants of unknown significance
• Functional annotations of variants 
• Molecular modeling of the effects of cancer mutations
• High-throughput mutational scans in silico
• Data management and maintenance of databases

Candidates will be computational biologists with strong communication and interpersonal skills to work on a daily base with biologists and clinicians. Supervision will be available on the different aspects of the research to facilitate candidates independently driving the research areas.
The position is based at DTU and change of research environment will be planned within the groups involved in ELEGANT North to enhance translational research.
Candidates should be able to exhibit the following personal and professional qualifications:

• Confortable with UNIX/Linux environment and bash scripting. 
• Programming in R/Rstudio and python.
• Familiarity with Bioconductor packages
• Experience with data management.
• Experience with molecular modeling and protein structure analyses.
• Methods to predict protein-protein interactions or changes in protein stability upon mutations.
• Aptitude to biology and understand complex mechanisms.
• Strong written and spoken level of English.
• You enjoy working in a team, teaching to your colleagues and helping them with your knowledge and skills.
• Flexibility and self-motivation
• Capable of working efficiently individually and as a member of a team
• Experience with experimental assays in vitro or in cellular models can be an additional value but not requested for the position.

You must have a two-year master's degree (120 ECTS points) or a similar degree with an academic level equivalent to a two-year master's degree.
Approval and Enrolment 
The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see DTU's rules for the PhD education . 
Assessment
The assessment of the applicants will be made by end of March 2024.
We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.
Salary and appointment terms 
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. 
The period of employment is 3 years. Starting date is between 15 April 2024 and 1 May 2024 (or accoding to mutual agreement). The position is a full-time position.
You can read more about career paths at DTU here .
Further information 
Further information may be obtained from Dr. Elena Papaleo, [email protected] .
You can read more about DTU Health Tech at www.healthtech.dtu.dk/ .  
If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark . Furthermore, you have the option of joining our monthly free seminar “PhD relocation to Denmark and startup “Zoom” seminar ” for all questions regarding the practical matters of moving to Denmark and working as a PhD at DTU. 
Application procedure 
Your complete online application must be submitted no later than 6 March 2024 (23:59 Danish time). Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply now", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

• A letter motivating the application (cover letter).
• Curriculum vitae. 
• Grade transcripts and BSc/MSc diploma (in English) including official description of grading scale.
• The name for at least two references/recommendation from previous working or research experience.

You may apply prior to ob­tai­ning your master's degree but cannot begin before having received it. 
Applications received after the deadline will not be considered.
All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.
DTU Health Tech engages in research, education, and innovation base on technical and natural science for the healthcare sector. The Healthcare sector is a globally expanding market with demands for the most advanced technological solutions. DTU Health Tech creates the foundation for companies to develop new and innovative services and products which benefit people and create value for society. DTU Health Tech’s expertise spans from imaging and biosensor techniques, across digital health and biological modelling, to biopharma technologies. The department has a scientific staff of about 210 persons, 140 PhD students and a technical/administrative support staff of about 160 persons, of which a large majority contributes to our research infrastructure and related commercial activities.
Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.

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Job Info

• Job Identification 3221
• Job Category Phd
• Posting Date 02/21/2024, 09:27 AM
• Apply Before 03/06/2024, 05:59 PM
• Locations Ørsteds Plads, Kgs. Lyngby, 2800, DK

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