6 PhD fellowships in In Vivo Pharmacology, University of Copenhagen

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6 PhD fellowships in In Vivo Pharmacology

Department of Veterinary Disease Biology, Faculty of Life Sciences, University of Copenhagen, is offering 6 PhD fellowships commencing 1 February 2012 or soon thereafter. The application deadline is 13 January 2012.
 
The Faculty of Life Sciences and Novo Nordisk A/S have recently established a research centre - The Novo Nordisk-LIFE In Vivo Pharmacology Centre (LIFEPHARM) - with a total budget of 68 million DKK covering activities until the end of 2018. The present positions are part of the new Centre´s activities. The purpose of the research centre is to strengthen the research in experimental pharmacology and toxicology and to increase the output of candidates and PhDs with a strong in vivo pharmacological profile. It is expected that the future PhD fellows will be enrolled in the Danish In Vivo Pharmacology PhD programme at LIFE and participate actively in this network. The In Vivo Pharmacology PhD programme was established in 2006 as a collaboration between the Faculties of Life Sciences, Pharmaceutical Sciences and Health Sciences at the University of Copenhagen, University of Aarhus, and industrial partners; Novo Nordisk A/S, LEO Pharma and H. Lundbeck A/S.
 
Job description
Your key tasks as a PhD fellow at LIFE are:
  • Manage and carry through your research project
  • Take PhD courses
  • Write scientific articles and your PhD thesis
  • Participate in international congresses
  • Stay at a research institution abroad for a few months
  • Teach and disseminate your research

 
 
No. 1. PhD fellowship in pharmacology 
 
Project description
Traditional antimicrobial therapy guidelines are based on indirect modeling from blood antimicrobial levels. However, studies both in humans and animals have shown the fallacy of this concept in various tissues. Many different methods have been employed to study lung tissue antimicrobial levels, but each has limitations that diminish their utility. This project will focus on the microdialysis technique to obtain information on antimicrobial concentration profiles at the site of infections in pneumonia. Experimental studies will be conducted in healthy experimentally infected pigs with two classes of antimicrobials. Data emanating from these studies could inform decisions for appropriate dosing schedules of antimicrobial agents in pneumonia.
 
Principal supervisor
Professor Christian Friis, cfr@life.ku.dk Direct Phone: (+45) 35 33 31 61
Department of Veterinary Disease Biology
 
Required qualifications
  • DVM , MD or other relevant degree with in vivo focus
  • A special interest in experimental models, surgery and antimicrobial therapy

 
Preferred qualifications
  • Documented experience within the subject area or related areas
  • Category C qualifying course in animal experimentation

 
Apply online for project no 1
 
 
No. 2. PhD fellowship in in vivo clearance of rFVIIa 
 
Project description
Both from in vitro and in vivo distribution studies, it is well known that rFVIIa is found in both liver and kidney, but the extent to which they participate in the clearance process is not yet fully understood. The main objective of the present PhD will be to set up and validate in vivo bypass models, and to explore the clearance mechanism of compounds with partly unknown clearance mechanism in the models, e.g. rFVIIa and related biopharmaceuticals.
 
Principal supervisor
Professor Jens Lykkesfeldt, jopl@life.ku.dk Direct Phone: (+45) 35 33 31 63
Department of Veterinary Disease Biology
 
Required qualifications
  • DVM, MD, MSc in human biology or other relevant degree with in vivo focus
  • A special interest in topics such as in biomedicine, coagulation system, haemophilia and bleeding disorders
  • Surgical procedures will be essential for the project, so an interest in developing and testing new in vivo models is a requirement
  • A general interest in pharmacokinetic concepts

 
Preferred qualifications
  • Documented surgical experience within the subject area or related areas
  • Category C qualifying course in animal experimentation

 
Apply online for project no 2
 
 
No. 3. PhD fellowship in metabolic changes induced in non-diabetic rats following chronic hyperinsulinaemic hypoglycaemia 
 
Project description
The project objective is to generate a better understanding of the metabolic and endocrine effects of treatment with long-acting insulin in non-diabetic animals. A deeper insight into the counter regulatory mechanism to induced hypoglycaemia will ensure a relevant interpretation of findings in toxicological studies conducted for safety assessments of insulin analogues. The PhD student will develop a relevant experimental model to subsequently investigate the key hypotheses of the project.
 
Principal supervisor
Professor Jens Lykkesfeldt, jopl@life.ku.dk Direct Phone: (+45) 35 33 31 63
Department of Veterinary Disease Biology
 
Required qualifications
  • DVM, MD, MSc in human biology or other relevant degree with in vivo focus
  • A special interest in topics such as biomedicine and insulin physiology
  • Interest in developing and testing new in vivo models
  • A general interest in pharmacokinetic concepts
  • Good writing skills in English are a prerequisite

 
Preferred qualifications
  • Category C qualifying course in animal experimentation
  • The applicant exhibits creativity, openness to new challenges and interest in independent and nontrivial research.

 
Apply online for project no 3
 
 
No. 4. PhD fellowship in new in vivo cardiovascular biomarkers in an animal model of chronic mitral regurgitation
 
Project description
Changes in new advanced echocardiographic biomarkers of myocardial function will be correlated to changes in myocardial plasma biomarkers and local myocardial changes in a dog model of naturally occurring mitral regurgitation (MR). The prognostic significance of the echocardiographic changes for progression of MR will be evaluated. The PhD study is expected to contribute with new knowledge regarding cardiovascular imaging in animal models, mechanisms behind left ventricular dysfunction and hopefully improve future management of chronic MR in animals and humans.
 
Principal supervisor
Professor mso Lisbeth Høier Olsen, liho@life.ku.dk Direct Phone: (+45) 35 33 31 75
Department of Veterinary Disease Biology
 
Required qualifications
  • DVM   
  • A special interest in biomedicine and cardiovascular medicine

 
Preferred qualifications
  • Documented experience within the subject area or related areas
  • Category C qualifying course in animal experimentation

 
Apply online for project no 4
 
 
No. 5. PhD fellowship in modelling the impact of regulatory immunity on inflammatory disease in mouse models
 
Project description
The project will elucidate the mechanisms behind the gut microbial priming of the regulatory immune system in early life, and the impact that this priming has on development of disease later in life. This priming will be mimicked by microbial and chemical means in mouse models, and it will be studied in relation to the later development of colitis and type 2 diabetes also in mouse models. The models will be characterized by their clinical, immunological and microbial response. The project aims at understanding these basic mechanisms of the development of gut regulatory immunity aiming at, in the long run, to be able to control this pharmacologically, e.g. by stimulating a low regulatory response in pre-diabetic or pre-colitic patients. The final PhD will have basic competencies within immunopharmacology and animal experimentation, especially in mouse models and ex vivo methods applied within immunology.
 
Principal supervisor
Professor Axel Kornerup Hansen, akh@life.ku.dk Direct Phone: (+45) 35 33 27 26.
Department of Veterinary Disease Biology
 
Required qualifications
  • DVM or other relevant degree with focus on animal experimentation at the starting date of the project.
  • A special interest in biomedical topics such as pharmacology, microbiology and immunology
  • Some previous experience with laboratory methods within biomedical fields, such as immunology and microbiology.
  • A special interest in in vivo studies
  • Category C qualifying course in animal experimentation

 
Preferred qualifications  
  • Previous experience with gut microbial and immunological characterisation of animal models

 
Apply online for project no 5
 
 
No. 6.  PhD fellowship in predictive value of murine DTH monoarthritis for rheumatoid arthritis (RA)
 
Project description
The aim of the project is to develop, characterize and explore a new arthritis model that can help facilitate drug discovery and identify unknown drivers of inflammation in arthritis. The project will focus on both descriptive and hypothesis-driven studies with the perspective on dissecting and establishing the full potential and relevance of the model in relation to rheumatoid arthritis. The PhD candidate will collaborate internally and externally in the attempt to discover molecular pathways important to joint inflammation in vivo, including in vivo imaging of disease-relevant processes and collection of tissue and cells for gene-expression analysis. Finally, based on data generated in this project and published data, the applicant will evaluate and conclude on the applicability and predictive value of the arthritis models as pre-clinical models of human RA .
 
Principal supervisor
Associate Professor Søren Skov  E-mail: sosk@life.ku.dk Direct Phone: (+45) 35 33 31 26
Department of Veterinary Disease Biology
  
Required qualifications
  • MSc in human biology or other relevant degree with solid experience within In Vivo Pharmacology.
  • A special interest in topics such as immunology and autoimmunity with focus on T-cell dependent models of arthritis and delayed-type hypersensitivity (DTH).

 
Preferred qualifications
  • Documented experience with histology, flow cytometry (LSRII), bioplex/ELISA will be an advantage
  • You are fluent in English and have excellent communication skills.

 
Apply online for project no 6
 
 
Key criteria for the assessment of all candidates
 
  • The grade point average achieved
  • Professional qualifications relevant to the PhD programme
  • Previous publications
  • Relevant work experience
  • Other professional activities
  • Language skills
  • Interpersonal skills

 
Formal requirements
The positions are available for a 3-year period for applicants holding a relevant master´s degree.
 
The successful applicants to the PhD scholarships must pass an enrolment in the LIFE before the Faculty can finish the letters of employment. Graduate School
 
The Graduate of the Faculty of Life Sciences, LIFE strives to give our students the best international career prospects within our main research areas. School
 
Terms of employment
The positions will be filled according to the agreement between the Danish Ministry of Finance and the Danish Confederation of Professional Associations. The post is covered by the Protocol on Job Structure.
 
Application Procedure
Apply by clicking "Apply online" above for each project you are applying for.
Applications - in English - must include:
  • Cover Letter, stating for which PhD project you are applying and detailing your motivation and background for applying for the specific PhD project.
  • CV
  • Diploma and transcripts of records 
  • Other information for consideration, e.g. list of publications (if any), peer reviewed and other
  • Personal Recommendations
  • A maximum of 3 relevant scientific works that you wish to have included in the assessment.

 
The applicants will be assessed according to the Ministry of Science Technology and Innovation Executive Order no 284 of 25. April 2008.
 
By the end of March 2012, all applicants will have received information regarding the evaluation of their application. Receipt of the application will not be acknowledged.
 
The applications must be received no later than 13 January 2012. Applications received later than this date will not be considered.
Deadline: 13-01-2012
Publisher: Det Biovidenskabelige Fakultet
    

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