PhD in immunology/gene therapy: "Innovative solutions for gene editing in gene therapy targeting hematopoietic stem cells"
28 Mar 2024
Job Information
- Organisation/Company
Université Libre de Bruxelles (ULB)- Department
Institute for Medical Immunology (IMI)- Research Field
Medical sciences » Medicine- Researcher Profile
First Stage Researcher (R1)- Country
Belgium- Application Deadline
18 May 2024 - 00:00 (Europe/Brussels)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
38- Offer Starting Date
1 Jul 2024- Is the job funded through the EU Research Framework Programme?
Not funded by an EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
This PhD offer is part of the GT4Health project, funded by the Walloon Region as part of its Win4Excellence program. It aims to develop various disruptive technologies as solutions to major challenges in the gene therapy sector. This multidisciplinary project involves ten partners from five French-speaking Belgian universities (ULiège, ULB, UCL, UNamur and UMons), as well as the CER Groupe research centre. In this project, viral and non-viral vectors will be used to develop innovative personalised therapeutic solutions, enabling researchers to tackle serious hereditary and chronic diseases and cancers by validating a variety of therapeutic targets.
Specifically, the project will aim to develop innovative genome-editing solutions for gene therapy on autologous hematopoietic stem cells
Gene therapy using autologous hematopoietic stem cells (HSCs) represents a major advance in the treatment of monogenic primary immunodeficiencies or hemoglobinopathies. The aim of this project is to develop a "toolbox" combining several innovative modalities to optimize genome editing in human HSCs that will be evaluated in vitro and in vivo (humanized mice models). This project will be a collaborative effort between the Institute of Medical immunology - ULB Center for Research in Immunology (U-CRI ) located in the BIOPARK campus (Gosselies) and the Cell Biology Laboratory (UMONS). We offer a 4-yr PhD fellowship. For more information and application, please contact Stanislas GORIELY ([email protected] ) or Lionel TAFFOREAU ([email protected] ). Please send your CV (including 2 external references) and motivation letter/personal statement.
Requirements
- Research Field
- Medical sciences » Health sciences
- Education Level
- Master Degree or equivalent
Skills/Qualifications
- Good knowledge of English
- Previous experience in molecular biology (gene editing, cloning) and cell culture
- Previous experience in small animal handling
Specific Requirements
Previous work with primary cells, viral vectors and CRISPR/cas9 approaches is an asset
- Languages
- ENGLISH
- Level
- Good
- Research Field
- Medical sciences » Health sciences
- Years of Research Experience
- None
Additional Information
Benefits
Work contract for up to 4 years
Join a dynamic team of PhD students, post-docs, technicians and permanent staff and be part of a global project involving several universities
Access to cutting-edge technical platforms
Access to a doctoral training program
Eligibility criteria
Hold a Master degree
Knowledge in molecular biology
Selection process
After passing the eligibility check, the applications will be evaluated by the two project promoters in order to prepare a shortlist of candidates. This assessment will be based on motivation, the match between the scientific/technical background and the requirements of the PhD project. Shortlisted candidates will be interviewed by Teams or by phone and will be invited to visit the laboratory.
Additional comments
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Université Libre de Bruxelles
- Country
- Belgium
- City
- Gosselies
- Postal Code
- 6041
- Street
- 8 Rue Adrienne Bolland
- Geofield
Where to apply
[email protected]
Contact
- City
Gosselies- Website
https://u-cri.ulb.be- Street
A Bolland, 8- Postal Code
6041
[email protected]
[email protected]
STATUS: EXPIRED
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