Staff Scientist - Mitochondria and Surgery

The Division of Thoracic Surgery of the Michael E. DeBakey Department of Surgery at Baylor College of Medicine is seeking a Staff Scientist in basic and translational research in mesothelioma and esophageal cancer. The Staff Scientist will be the primary scientist to evaluate mitochondria pathways associated with treatment resistance in esophageal cancer. This project will focus on the epigenetic and mitochondrial mechanisms that prevent response to immunotherapy or chemotherapy directly in human tumor samples as well as mice and cell culture. The project will require in vivo assessment in mouse models including already developed patient-derived xenografts (PDX) and patient-derived explants (PDE). Additionally, this position will require some oversight of our mesothelioma project especially with teaching post-doctoral fellows, graduate students, or post-baccalaureate students.

• Design, plan and execute tumor metabolism experiments including Seahorse XF assays and mitochondrial imaging
• Design, plan and execute metabolomics experiments
• Design, plan and perform basic molecular biology and cell culture techniques
• Train fellows and students on basic molecular biology and cell culture techniques
• Design, plan and perform experiments using mutation detection, gene expression profiling, chromatin immunoprecipitation, DNA/RNA-protein interactions cell culture, lentiviral transductions, and transcriptomic analysis
• Design, plan and execute experiments with patient tumor samples
• Design, plan and execute in vivo experiments using mouse models
• Perform biostatistical analysis of metabolomic and transcriptomic data
• Mentor students and postdocs in the lab
• Write manuscripts and grant applications
• Perform other job related duties as assigned.

• Doctoral Degree. Experience may not be substituted in lieu of degree.
• Three years of post doctoral research experience.

• Advanced skills with basic molecular biology techniques (western blot, PCR, cell culture, transfection)
• Mouse models experience
• Experience with lentiviral transductions
• Thoracic oncology experience is a plus

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.