Senior Research Specialist

Department of Computational and Systems Biology and the Hillman Cancer Center at the University of Pittsburgh Medical Center (UPMC) in the lab of Dr. Yu-Chih Chen (Chen Lab) is seeking a qualified individual who will establish and perform high-throughput single-cell analysis and analyze the data using machine learning approaches for clinical research. Due to genomic and epigenetic instability of cancer cells, inter-patient and intra-patient heterogeneity in tumors creates formidable challenges in identifying optimal treatments. To address the challenges, we aim to establish comprehensive high-throughput multi-omics single-cell analysis including genome, epigenome, transcriptome, proteome, functional, and morphological methods. With large amounts of data collected from high-throughput single-cell multi-omics analysis, machine learning techniques can predict patient prognosis and suggest treatments for precision medicine. The integrated approach will change how we understand and treat cancer and ultimately improve outcomes for patients. We seek a creative individual who will develop a cutting-edge research program and lead collaborative research initiatives on the development, use, and dissemination of novel methods from computational, physical sciences and/or engineering sciences to address current challenges in computational and systems biology and to facilitate the translation of basic research into clinical applications. Additional responsibilities will include, but not be limited to: – Preparing and monitoring budgets – Ordering reagents and laboratory equipment – Maintaining Laboratory Safety guidelines from the government and the university – Developing procedures and pipelines – Introducing novel technologies to the laboratory – Coordinating research activity, including data generation, quality control analyses, freezer stock organization and data storage – Training and supervising various personnel – Writing, editing, and figure preparation for grants and manuscripts – Presenting research within and outside university (posters, talks)

Job Summary

Performs a variety of independent laboratory work and experiments such as determining experimental protocols and preparation of specimens and cultures. Prepares reports of findings subsequent to compilation and analyzation. Oversees specimen inventory. Develops documentation for publication; crafts manuscripts and grant proposals.

Essential Functions 

Performing lab experiments at the bench. Keeping the lab organized and stocked. Providing technical assistance to lab members.

Standing for about an hour at a time is expected as well as some bending. Microscope work may require sitting for extended period of time.

The University of Pittsburgh is committed to championing all aspects of diversity, equity, inclusion, and accessibility within our community. This commitment is a fundamental value of the University and is crucial in helping us advance our mission, which includes attracting and retaining diverse workforces. We will continue to create and maintain an environment that allows individuals to discover, belong, contribute, and grow, while honoring the experiences, perspectives, and unique identities of all.

The University of Pittsburgh is an Affirmative Action/Equal Opportunity Employer and values equality of opportunity, human dignity and diversity. EOE, including disability/vets.