Senior Manager, Advanced Gene Therapy Designs - 128771

UCSD Layoff from Career Appointment: Apply by 03/20/2024 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor.

Special Selection Applicants: Apply by 04/01/2024. Eligible Special Selection clients should contact their Disability Counselor for assistance.

In 2022, businessman and philanthropist T. Denny Sanford committed $150 million to the creation of the Sanford Stem Cell Institute at UC San Diego. This gift combines current infrastructure with new Centers intended to leverage the advantages of space-based science, including expansion and, in some ways, quite literally launch stem cell research and regenerative medicine at UC San Diego into new spaces, endeavors, and training of future stem cell scientists.

Sanford Stem Cell Institute provides essential physical and human resources needed to leverage stem cell research currently being conducted at UC San Diego. Due to the complexity of regenerative medicine projects and substantial institutional investment, daily Sanford Stem Cell Institute personnel work with all 9 Vice Chancellor areas: Academic Affairs; Research Affairs; Equality, Diversity, and Inclusion; Student Affairs; Marine Sciences; Health Sciences; Health System; Chief Financial Officer; Advancement; Resource Management and Planning.

As part of UC San Diego, Sanford Stem Cell Institute motivates University-wide change, sustainability, and partnership, focusing on creating the structure under which various innovative regenerative medicine units and initiatives are developed.

The new UC San Diego Sanford Stem Cell Institute builds upon a $100 million gift in 2013 from T. Denny Sanford that established UC San Diego as a leader in developing and delivering the therapeutic promise of human stem cells - special cells with the ability to develop into many different cell types and which, when modified and repurposed, have the potential to treat, remedy or cure a vast array of conditions and diseases.

The new UC San Diego Sanford Stem Cell Institute includes six (6) stem cell Centers led by Center Directors and Co-Directors.

The Stem Cell Innovation Center (SCIC) is dedicated to pioneering advancements at the nexus of genomics, stem cell biology, and cutting- edge technologies, with a mission to expedite the translation of scientific insights into tangible therapies. Our vision encompasses a profound commitment to addressing paramount healthcare challenges, particularly in the domains of aging-related afflictions, cancer, and neurodegeneration. By propelling the frontiers of genomic technologies, harnessing the potential of stem cell models, accelerating translational impact, synergizing artificial intelligence with novel genomic modalities, and targeting critical health frontiers, we strive to redefine the landscape of medical innovation, ushering in a new era of transformative healthcare and tangible patient outcomes.

The incumbent Uses skills as a seasoned, experienced engineering professional in a specialized engineering field on a major training and / or research effort. Assignments typically require concentration in a field of application where subject matter knowledge relevant to research objectives and methodology is of great value in understanding and establishing engineering design criteria. Demonstrates good judgment in selecting methods and techniques for obtaining solutions. Under the direction of the Center’s Director, the Senior Manager will lead in designing, developing, managing, and executing the research platform of Advanced Gene Therapy Designs research platform including process development for viral vector engineering and delivery, vaccine development, and genome editing. The incumbent will collaborate with other investigators within the center and oversee a team of research associates and bioinformatic programmers who focus on genomic technology development.

The Senior Manager will be responsible for advancing genomic and virus engineering technologies, scientific publications, overseeing research projects, and assisting in all elements of program administration. The incumbent will represent the center by giving talks on research progress and accomplishments in internal and external meetings, seminars, and conferences. The position will also collaborate with other investigators intra- and inter-institutionally or with industry partners to design, develop, and execute research projects that use the Advanced Gene Therapy Designs technologies under the Sanford Stem Cell Innovation Center. Performs other duties as assigned.

• Seven years of related experience, education/training, OR an Bachelor’s degree in related area plus three years of related experience/training.

• Thorough knowledge and experience with engineering principles and methods to independently perform the full range of engineering professional design work. Academic and/or industry background and experience in selected area of research. Experience in virus engineering and vaccine development. Ph.D. in a relevant field preferred with at least three (3) years of relevant post-degree experience. Expertise in the fields of virology, cellular and molecular biology, genomics, and AAV capsid engineering.

• Thorough knowledge necessary to apply principles, practices and procedures in the completion of assignments. Hands-on experience in virus (AAV) engineering and production process development and analysis, and vaccine development. Extensive knowledge of virology, animal husbandry, mammalian protein expression system, and next-generation sequencing.

• Demonstrated organizational and decision-making abilities to prioritize competing work assignments in order to meet deadlines and adherence to quality standards.

• Strong analytical and judgment skills to independently conduct analyses and develop appropriate recommendations.

• Effective written and verbal communication and presentation skills.

• Ability to work in a collaborative manner; identify challenges and barriers and recommend resolutions.

• Ability to lead and influence others.

• Employment is subject to a criminal background check.

• Irregular hours or on evenings/weekends/holidays as required.

• Willing to work in an environment with biological, chemical, and radiological hazards, and with human Embryonic Stem Cells and animal models.

• Occasional travel.

Pay Transparency Act

Annual Full Pay Range: $82,500 - $151,500 (will be prorated if the appointment percentage is less than 100%)

Hourly Equivalent: $39.51 - $72.56

Factors in determining the appropriate compensation for a role include experience, skills, knowledge, abilities, education, licensure and certifications, and other business and organizational needs. The Hiring Pay Scale referenced in the job posting is the budgeted salary or hourly range that the University reasonably expects to pay for this position. The Annual Full Pay Range may be broader than what the University anticipates to pay for this position, based on internal equity, budget, and collective bargaining agreements (when applicable).

If employed by the University of California, you will be required to comply with our Policy on Vaccination Programs, which may be amended or revised from time to time. Federal, state, or local public health directives may impose additional requirements.

If applicable, life-support certifications (BLS, NRP, ACLS, etc.) must include hands-on practice and in-person skills assessment; online-only certification is not acceptable.

UC San Diego Health Sciences is comprised of our School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, The Herbert Wertheim School of Public Health and Human Longevity Science, and our Student Health and Well-Being Department. We have long been at the forefront of translational - or "bench-to-bedside" - research, transforming patient care through discovery and innovation leading to new drugs and technologies. Translational research is carried out every day in the hundreds of clinical trials of promising new therapies offered through UC San Diego Health, and in the drive of our researchers and clinician-scientists who are committed to having a significant impact on patient care. We invite you to join our team!

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