Scientist - ADC Chemistry

At Pfizer we deliver breakthroughs that change patients' lives with the mission to outdo cancer. The ADC (Antibody-Drug-Conjugate) chemistry team plays a vital role in this mission through discovering and advancing novel ADC linker/payload technologies for targeted cancer therapies. We are looking for a highly motivated, creative, and collaborative researcher to join our ADC chemistry team in a lab-based role in Bothell Washington to support novel ADC technology development. The successful candidate will participate in research projects involving the design and synthesis of novel ADC payloads and drug linkers. Activities may also include coordinating or performing biological assays to understand drug linker and ADC properties

KEY RESPONSIBILITIES

• Design and perform multi-step syntheses for novel ADC payloads, drug linkers, and key intermediates
  
• Work independently to develop, troubleshoot and optimize synthetic routes, including modular routes for rapid analog generation and efficient scalable routes for early-stage drug candidates
  
• Operate in a variety of analytical instruments and technologies including HPLC, LC/MS, NMR to enable structural determination and purity assessment
  
• Work effectively in both independent and highly collaborative settings
  
• Analyze and accurately record data using Electronic Laboratory Notebooks
  
• Actively participate in discussions and present results in the form of written reports and oral presentations
  
• Adhere to all company safety, scientific record keeping, and compliance requirements
  

Qualifications

• Master's degree with 4+ years or bachelor's degree with 6+ years industrial experience as a synthetic organic chemist
  
• Deep understanding of organic functional groups, reaction mechanisms and reactivity.
  
• Ability to use chemistry and literature/patent searching software to plan and execute synthetic strategies
  
• Proven record as a synthetic organic chemist familiar with a wide range of reaction types and having demonstrated multi-step synthesis, purification and characterization of organic compounds, especially using NMR and mass spectroscopy
  
• Strong interpersonal skills and effective written/verbal communication
  
• Ability to work effectively in multi-disciplinary teams, learn new skills and proactively solve problems
  

\nRelocation support available\n

The annual base salary for this position ranges from $74,900.00 to $124,800.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development