Researcher 6

Details

Posted: 12-Mar-24

Location: Minneapolis, Minnesota

Salary: 54,467.46 - 152,485.17

Categories:

Research - Laboratory/Non-Laboratory
Staff/Administrative

Internal Number: 360112

Position Summary
This is a research position within a laboratory at the interface of virology, microbial ecology and mucosal immunology studying mechanisms by which respiratory viruses like influenza and respiratory syncytial virus cause disease in humans.  The position offers the opportunity to interact with physician-scientists and develop skills in a variety of research techniques, experimental approaches and research questions relevant to human health, including primary human cell culture, molecular virology and analysis of multiomics data.
The Researcher 6 is expected to design and independently manage one or more research projects. After consultation with the PI on scope, the successful candidate will be expected to identify appropriate methodology, execute experiments, and report results independently.
The successful candidate will act as a secondary mentor and supervisor for trainees in the laboratory, assisting them with project design and experiments when appropriate. 
The researcher will be expected to be able to independently draft manuscript and grant applications and will have opportunities to submit applications for funding as a co-PI or Co-I.
Assist with the day-to-day management of the lab, including ordering, compliance, and budget management.
Represent the research group scientifically at an international level. Network with other scientific colleagues and help build and maintain collaborations that will drive the research program forward.
Our lab seeks to foster an inclusive environment in which members from diverse backgrounds are encouraged to develop their skills of scientific inquiry. A successful candidate will be a curious, self-motivated team player.  
This position supports flexible work hours upon prior arrangement with PI.  The candidate in this position will be designated as an Essential Employee.  Essential Employees are expected to report to campus during a University State of Emergency (reduced operations or campus closure) unless specifically directed by the Department not to report or if directed by civil emergency or medical authorities not to report for health and safety reasons.  As an Essential Employee, the candidate must report to campus even if the closure if less than 3 days.
Duties/Responsibilities
60% Experiment design and execution.
Development and execute molecular assays for detection of human microbial pathogens (nucleic acid extraction, reverse transcription, PCR, qPCR)
Next-generation sequencing (development of hybrid capture assays for respiratory pathogen genome sequencing, 16S rRNA sequencing, 28S/ITS rRNA sequencing)
In vitro experimentation in human respiratory tract model systems (propagation of bacterial and/or fungal stocks, air-liquid interface microbial-viral-human cell co-culture systems, organoid culture)
Perform in vitro virological assays (preparation and titering of viral stocks, viral infection assays)
Perform assay of human immune function (multi-parameter flow cytometry, ELISA)
Expand repertoire of fungal studies within the lab
20% Data analysis and manuscript preparation.
Independent data analysis and figure preparation
Collaborate with PI on manuscript and grant writing.
Assist junior scientists with experimental design and troubleshooting and writing projects
20% Lab management and administration.
Assist with lab organization
Assist with maintenance of lab equipment
Supervise junior lab members in specimen kit shipping. receiving and logging in laboratory database for clinical studies (MINNE-LOVE and MINNE-LOVE-2)
Supervise junior members of the lab in reagent preparation
Co-mentor trainees (undergraduates, graduate students, and fellows) with the PI
Supervise inventory and ordering
Assist with research compliance (IBC, IRB)
Assist with laboratory financial management

Required Qualifications
- Advanced degree (e.g. PhD, MD, DVM) and a substantial research and publication record.
- At least 5 years of research experience, including experience in independent project management and supervision and mentorship of junior scientists
- Facility with standard molecular biology techniques, including nucleic acid extraction, reverse transcription, and PCR/qPCR
- Strong organizational skills
- Excellent written, verbal and interpersonal skills
- Ability to work independently and as a part of a diverse team
Preferred Qualifications
Experience with lab management
- Experience with next-generation sequencing techniques (Oxford Nanopore preferred)
- Experience with standard microbial culture techniques (bacterial, fungal)
- Familiarity with concepts of microbial phylogeny and associated analysis tools
- Familiarity with R and/or Python, ability to perform basic bioinformatic analyses independently and work with more experienced bioinformaticians for more complex analyses
- Experience with risk-mitigation strategies for handling potentially infectious human pathogens in a BSL-2 enviroment
- Experience with standard mammalian tissue culture techniques
- Prior training and experience conducting research involving human subjects or willingness to complete such training (CITI, HIPAA)

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About University of Minnesota Twin Cities
The University of Minnesota, founded in the belief that all people are enriched by understanding, is dedicated to the advancement of learning and the search for truth; to the sharing of this knowledge through education for a diverse community; and to the application of this knowledge to benefit the people of the state, the nation, and the world.
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